| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSNK1A1 | FAM83E | ENSP00000261798 | ENSP00000263266 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | 0.519 |
| EMP3 | FAM83E | ENSP00000469194 | ENSP00000263266 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | 0.432 |
| FAM83E | CSNK1A1 | ENSP00000263266 | ENSP00000261798 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. | 0.519 |
| FAM83E | EMP3 | ENSP00000263266 | ENSP00000469194 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions. | 0.432 |
| FAM83E | FUT2 | ENSP00000263266 | ENSP00000387498 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. | 0.430 |
| FAM83E | GUCA1B | ENSP00000263266 | ENSP00000230361 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). | 0.457 |
| FAM83E | KIF22 | ENSP00000263266 | ENSP00000160827 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | 0.444 |
| FAM83E | TRIM62 | ENSP00000263266 | ENSP00000291416 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | E3 ubiquitin-protein ligase TRIM62; E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2; Belongs to the TRIM/RBCC family. | 0.467 |
| FAM83E | TTBK2 | ENSP00000263266 | ENSP00000267890 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. | 0.443 |
| FAM83E | TTLL11 | ENSP00000263266 | ENSP00000321346 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Tubulin polyglutamylase TTLL11; Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Generates long side-chains (By similarity). | 0.464 |
| FAM83E | ZNF362 | ENSP00000263266 | ENSP00000446335 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Zinc finger protein 362; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.455 |
| FAM83E | ZSCAN20 | ENSP00000263266 | ENSP00000355053 | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.454 |
| FUT2 | FAM83E | ENSP00000387498 | ENSP00000263266 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | 0.430 |
| FUT2 | ZSCAN20 | ENSP00000387498 | ENSP00000355053 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. | Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.401 |
| GUCA1B | FAM83E | ENSP00000230361 | ENSP00000263266 | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | 0.457 |
| GUCA1B | TRIM62 | ENSP00000230361 | ENSP00000291416 | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). | E3 ubiquitin-protein ligase TRIM62; E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2; Belongs to the TRIM/RBCC family. | 0.414 |
| GUCA1B | TTLL11 | ENSP00000230361 | ENSP00000321346 | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). | Tubulin polyglutamylase TTLL11; Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Generates long side-chains (By similarity). | 0.459 |
| GUCA1B | ZNF362 | ENSP00000230361 | ENSP00000446335 | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). | Zinc finger protein 362; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.450 |
| GUCA1B | ZSCAN20 | ENSP00000230361 | ENSP00000355053 | Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). | Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.469 |
| KIF22 | FAM83E | ENSP00000160827 | ENSP00000263266 | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. | Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family. | 0.444 |