STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SISucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs to the glycosyl hydrolase 31 family (1827 aa)    
Predicted Functional Partners:
AMY2A
Pancreatic alpha-amylase; Amylase, alpha 2A
  
 
 0.977
GLA
Alpha-galactosidase a; Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family
   
 
 0.961
AMY1B
Amylase, alpha 1b; Belongs to the glycosyl hydrolase 13 family
  
 
 0.959
AMY2B
Amylase, alpha 2B; Belongs to the glycosyl hydrolase 13 family
  
 
 0.951
GANC
Glucosidase alpha, neutral c; Neutral alpha-glucosidase C; Has alpha-glucosidase activity
     
0.925
KHK
Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate; Belongs to the carbohydrate kinase PfkB family
   
 
 0.912
HKDC1
Putative hexokinase HKDC1; Hexokinase domain containing 1
   
 
 0.909
GAA
Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans
     
0.907
MGAM
Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing
   
 
0.907
HK1
Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively) Does not phosphorylate N-acetyl-D-glucosamine . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan . W [...]
   
 
 0.905
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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