STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C2orf83Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. (150 aa)    
Predicted Functional Partners:
NOTO
Homeobox protein notochord; Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (By [...]
   
    0.793
LRRD1
Leucine rich repeats and death domain containing 1.
   
    0.774
C8orf86
Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86.
   
    0.630
OR7D2
Olfactory receptor 7D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
   
    0.577
CCDC27
Coiled-coil domain containing 27.
   
    0.535
IZUMO2
Izumo sperm-egg fusion protein 2; IZUMO family member 2.
   
    0.530
ZNF716
Zinc finger protein 716; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
   
   0.495
SPATA31A7
Spermatogenesis-associated protein 31A7; May play a role in spermatogenesis; Belongs to the SPATA31 family.
   
    0.479
DAND5
DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). Belongs to the DAN family.
   
  
 0.467
CELA2B
Chymotrypsin-like elastase family member 2B; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.
   
  
 0.466
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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