node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD20A2 | C2orf42 | ENSP00000366826 | ENSP00000264434 | Ankyrin repeat domain-containing protein 20A2. | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.579 |
ANKRD20A2 | GOLGA6C | ENSP00000366826 | ENSP00000300576 | Ankyrin repeat domain-containing protein 20A2. | Golgin A6 family member C; Belongs to the GOLGA6 family. | 0.752 |
APPL2 | C2orf42 | ENSP00000446917 | ENSP00000264434 | DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 lea [...] | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.523 |
C2orf42 | ANKRD20A2 | ENSP00000264434 | ENSP00000366826 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Ankyrin repeat domain-containing protein 20A2. | 0.579 |
C2orf42 | APPL2 | ENSP00000264434 | ENSP00000446917 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 lea [...] | 0.523 |
C2orf42 | GOLGA6C | ENSP00000264434 | ENSP00000300576 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Golgin A6 family member C; Belongs to the GOLGA6 family. | 0.720 |
C2orf42 | MYBBP1A | ENSP00000264434 | ENSP00000370968 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Myb-binding protein 1A; May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1. Belongs to the MYBBP1A family. | 0.496 |
C2orf42 | RSBN1L | ENSP00000264434 | ENSP00000334040 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Lysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family. | 0.679 |
C2orf42 | VIPAS39 | ENSP00000264434 | ENSP00000452181 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indir [...] | 0.451 |
C2orf42 | ZBTB49 | ENSP00000264434 | ENSP00000338807 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Zinc finger and BTB domain-containing protein 49; Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.480 |
C2orf42 | ZNF557 | ENSP00000264434 | ENSP00000252840 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Zinc finger protein 557; May be involved in transcriptional regulation. | 0.467 |
C2orf42 | ZNF79 | ENSP00000264434 | ENSP00000362446 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Zinc finger protein 79; May be involved in transcriptional regulation. | 0.632 |
C2orf42 | ZSCAN32 | ENSP00000264434 | ENSP00000380061 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.457 |
GOLGA6C | ANKRD20A2 | ENSP00000300576 | ENSP00000366826 | Golgin A6 family member C; Belongs to the GOLGA6 family. | Ankyrin repeat domain-containing protein 20A2. | 0.752 |
GOLGA6C | C2orf42 | ENSP00000300576 | ENSP00000264434 | Golgin A6 family member C; Belongs to the GOLGA6 family. | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.720 |
MYBBP1A | C2orf42 | ENSP00000370968 | ENSP00000264434 | Myb-binding protein 1A; May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1. Belongs to the MYBBP1A family. | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.496 |
RSBN1L | C2orf42 | ENSP00000334040 | ENSP00000264434 | Lysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family. | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.679 |
VIPAS39 | C2orf42 | ENSP00000452181 | ENSP00000264434 | Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indir [...] | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.451 |
VIPAS39 | ZSCAN32 | ENSP00000452181 | ENSP00000380061 | Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B. May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indir [...] | Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.440 |
ZBTB49 | C2orf42 | ENSP00000338807 | ENSP00000264434 | Zinc finger and BTB domain-containing protein 49; Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. [Isoform 3]: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family. | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42. | 0.480 |