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CSTA protein (human) - STRING interaction network
"CSTA" - Cystatin-A in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CSTACystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin family (98 aa)    
Predicted Functional Partners:
CTSB
Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins (339 aa)
     
 
  0.977
IVL
Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family (585 aa)
     
  0.960
LOR
Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family (312 aa)
       
  0.955
TGM1
Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation; Belongs to the transglutaminase superfamily. Transglutaminase family (817 aa)
     
 
  0.954
CTSL
Cathepsin L1; Important for the overall degradation of proteins in lysosomes; Cathepsins (333 aa)
       
 
  0.952
PI3
Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing (117 aa)
     
  0.947
DSP
Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family (2871 aa)
       
  0.937
FLG
Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing (4061 aa)
         
  0.937
CDSN
Corneodesmosin; Important for the epidermal barrier integrity (529 aa)
         
  0.935
EVPL
Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins (2033 aa)
       
  0.934
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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