STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAPGEFL1Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF). (662 aa)    
Predicted Functional Partners:
OGFOD3
2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family.
      
 0.560
WIPF2
WAS/WASL-interacting protein family member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
 
 
  
 0.478
SERAC1
Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.
      
 0.472
RAPGEF5
Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
  
 
0.463
GPRIN1
G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth.
   
  
 0.448
LIN52
Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component.
      
 0.446
AMZ1
Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.
      
 0.444
MAP6D1
MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family.
   
  
 0.443
FAM118A
Protein FAM118A; Family with sequence similarity 118 member A.
      
 0.423
RNFT2
Ring finger protein, transmembrane 2.
      
 0.421
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.