node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC87 | FAM184B | ENSP00000328487 | ENSP00000265018 | Coiled-coil domain-containing protein 87; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility; Belongs to the CCDC87 family. | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.451 |
DCAF16 | FAM184B | ENSP00000371682 | ENSP00000265018 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.759 |
DCAF16 | LCORL | ENSP00000371682 | ENSP00000371661 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.716 |
DCAF16 | MED28 | ENSP00000371682 | ENSP00000237380 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex [...] | 0.563 |
DCAF16 | NCAPG | ENSP00000371682 | ENSP00000251496 | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.723 |
FAM13A | FAM184B | ENSP00000264344 | ENSP00000265018 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.444 |
FAM184B | CCDC87 | ENSP00000265018 | ENSP00000328487 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Coiled-coil domain-containing protein 87; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility; Belongs to the CCDC87 family. | 0.451 |
FAM184B | DCAF16 | ENSP00000265018 | ENSP00000371682 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | 0.759 |
FAM184B | FAM13A | ENSP00000265018 | ENSP00000264344 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family. | 0.444 |
FAM184B | IBSP | ENSP00000265018 | ENSP00000226284 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | 0.450 |
FAM184B | LCORL | ENSP00000265018 | ENSP00000371661 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | 0.777 |
FAM184B | MED28 | ENSP00000265018 | ENSP00000237380 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex [...] | 0.594 |
FAM184B | MEPE | ENSP00000265018 | ENSP00000378534 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation. Belongs to the PF07175/osteoregulin family. | 0.457 |
FAM184B | NCAPG | ENSP00000265018 | ENSP00000251496 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. | 0.747 |
FAM184B | PACRGL | ENSP00000265018 | ENSP00000423881 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | PACRG-like protein; Parkin coregulated like. | 0.588 |
FAM184B | SPTY2D1 | ENSP00000265018 | ENSP00000337991 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4. Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holli [...] | 0.461 |
IBSP | FAM184B | ENSP00000226284 | ENSP00000265018 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.450 |
IBSP | MEPE | ENSP00000226284 | ENSP00000378534 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation. Belongs to the PF07175/osteoregulin family. | 0.790 |
LCORL | DCAF16 | ENSP00000371661 | ENSP00000371682 | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins. | 0.716 |
LCORL | FAM184B | ENSP00000371661 | ENSP00000265018 | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis (By similarity). | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family. | 0.777 |