STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1257Uncharacterized protein KIAA1257. (409 aa)    
Predicted Functional Partners:
CCDC180
Coiled-coil domain containing 180.
    
 
 0.717
LRGUK
Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.
   
 
 0.684
SPATA17
Spermatogenesis-associated protein 17; Spermatogenesis associated 17.
   
 
 0.680
SPAG17
Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts.
   
 
 0.670
DLEC1
Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation.
   
 
 0.614
CCDC113
Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.
   
  
 0.610
CFAP221
Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis.
   
 
 0.591
SPAG6
Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
   
 
 0.560
DMAP1
DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...]
    
 
 0.559
LRRC72
Leucine-rich repeat-containing protein 72; Leucine rich repeat containing 72.
    
 
 0.543
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
Server load: medium (42%) [HD]