STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FSCN3Fascin-3; Acts as an actin bundling protein; Belongs to the fascin family. (498 aa)    
Predicted Functional Partners:
TMEM225
Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.
   
  
 0.675
IQCF1
IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction.
   
  
 0.543
FNDC8
Fibronectin type III domain containing 8.
   
  
 0.542
GCC1
GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure.
   
  
 0.540
TMEM270
Transmembrane protein 270.
      
 0.531
FAM71F1
Protein FAM71F1; Family with sequence similarity 71 member F1.
   
  
 0.524
KLHL10
Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.
   
  
 0.480
GTSF1L
Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like.
   
  
 0.479
TMEM225B
Transmembrane protein 225B.
      
 0.460
CCDC182
Coiled-coil domain containing 182.
      
 0.442
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.