node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASTN2 | GLT8D1 | ENSP00000354504 | ENSP00000266014 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | 0.512 |
ASTN2 | KLHL42 | ENSP00000354504 | ENSP00000370671 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | Kelch-like protein 42; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. | 0.418 |
C6orf136 | GLT8D1 | ENSP00000293604 | ENSP00000266014 | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136. | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | 0.539 |
C6orf136 | SPCS1 | ENSP00000293604 | ENSP00000233025 | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. | 0.435 |
GLT8D1 | ASTN2 | ENSP00000266014 | ENSP00000354504 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup. | 0.512 |
GLT8D1 | C6orf136 | ENSP00000266014 | ENSP00000293604 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136. | 0.539 |
GLT8D1 | GNL3 | ENSP00000266014 | ENSP00000395772 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. | 0.594 |
GLT8D1 | ITIH3 | ENSP00000266014 | ENSP00000415769 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. | 0.517 |
GLT8D1 | KLHL42 | ENSP00000266014 | ENSP00000370671 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Kelch-like protein 42; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. | 0.514 |
GLT8D1 | MCF2L | ENSP00000266014 | ENSP00000440374 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42. | 0.510 |
GLT8D1 | NEK4 | ENSP00000266014 | ENSP00000233027 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.652 |
GLT8D1 | OR6C65 | ENSP00000266014 | ENSP00000368986 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Olfactory receptor 6C65; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.581 |
GLT8D1 | SPCS1 | ENSP00000266014 | ENSP00000233025 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. | 0.567 |
GLT8D1 | SUPT3H | ENSP00000266014 | ENSP00000360515 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | Transcription initiation protein SPT3 homolog; Probable transcriptional activator. | 0.543 |
GNL3 | GLT8D1 | ENSP00000395772 | ENSP00000266014 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | 0.594 |
GNL3 | ITIH3 | ENSP00000395772 | ENSP00000415769 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. | Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. | 0.421 |
GNL3 | NEK4 | ENSP00000395772 | ENSP00000233027 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. | 0.500 |
GNL3 | SPCS1 | ENSP00000395772 | ENSP00000233025 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. | 0.443 |
ITIH3 | GLT8D1 | ENSP00000415769 | ENSP00000266014 | Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family. | 0.517 |
ITIH3 | GNL3 | ENSP00000415769 | ENSP00000395772 | Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. | 0.421 |