STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM117Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family. (514 aa)    
Predicted Functional Partners:
NELL2
Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity).
      
 0.663
SLC2A13
Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
   
  
 0.529
KBTBD12
Kelch repeat and BTB domain containing 12.
      
 0.525
ZCRB1
Zinc finger CCHC-type and RNA binding motif containing 1.
   
  
 0.512
TMEM161B
Transmembrane protein 161B; Belongs to the TMEM161 family.
   
  
 0.509
NAALADL2
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; May be catalytically inactive; Belongs to the peptidase M28 family. M28B subfamily.
   
  
 0.460
GXYLT1
Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
   
  
 0.458
SCAF11
Protein SCAF11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.
   
  
 0.455
USP17L7
Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7; Ubiquitin specific peptidase 17 like family member 7.
      
 0.445
ANO6
Anoctamin-6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium- dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chlori [...]
   
  
 0.442
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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