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TMTC3 protein (human) - STRING interaction network
"TMTC3" - Transmembrane and TPR repeat-containing protein 3 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TMTC3Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing (914 aa)    
Predicted Functional Partners:
QSER1
Glutamine and serine rich 1 (1735 aa)
     
   
  0.767
PRR14L
Protein PRR14L; Proline rich 14 like (2151 aa)
           
  0.729
NANS
Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively (359 aa)
           
  0.708
TMEM201
Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (666 aa)
           
  0.680
DHRS7
Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily (339 aa)
       
 
  0.646
TMEM199
Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis (208 aa)
     
   
  0.644
POPDC2
Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family (364 aa)
           
  0.640
LMBRD2
LMBR1 domain containing 2 (695 aa)
     
        0.636
C17orf62
Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 (187 aa)
           
  0.621
BIVM
Basic, immunoglobulin-like variable motif containing (503 aa)
           
  0.607
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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