node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMDHD1 | AOX1 | ENSP00000266736 | ENSP00000363832 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | 0.688 |
AMDHD1 | CYP2R1 | ENSP00000266736 | ENSP00000334592 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). | 0.740 |
AMDHD1 | FTCD | ENSP00000266736 | ENSP00000380856 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. | 0.977 |
AMDHD1 | HAL | ENSP00000266736 | ENSP00000261208 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Histidine ammonia-lyase. | 0.969 |
AMDHD1 | MTAP | ENSP00000266736 | ENSP00000494373 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.742 |
AMDHD1 | NT5E | ENSP00000266736 | ENSP00000257770 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | 5'-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. | 0.814 |
AMDHD1 | PNP | ENSP00000266736 | ENSP00000354532 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.719 |
AMDHD1 | SEC23A | ENSP00000266736 | ENSP00000306881 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). Belongs to the SEC23/SEC24 family. SEC23 subfamily. | 0.716 |
AMDHD1 | UPRT | ENSP00000266736 | ENSP00000362481 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Uracil phosphoribosyltransferase homolog; Belongs to the UPRTase family. | 0.883 |
AMDHD1 | UROC1 | ENSP00000266736 | ENSP00000373073 | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | Urocanate hydratase 1. | 0.881 |
AOX1 | AMDHD1 | ENSP00000363832 | ENSP00000266736 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | 0.688 |
AOX1 | MTAP | ENSP00000363832 | ENSP00000494373 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.614 |
AOX1 | PNP | ENSP00000363832 | ENSP00000354532 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species [...] | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.662 |
CYP2R1 | AMDHD1 | ENSP00000334592 | ENSP00000266736 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | 0.740 |
CYP2R1 | SEC23A | ENSP00000334592 | ENSP00000306881 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity). Belongs to the SEC23/SEC24 family. SEC23 subfamily. | 0.506 |
FTCD | AMDHD1 | ENSP00000380856 | ENSP00000266736 | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | 0.977 |
FTCD | HAL | ENSP00000380856 | ENSP00000261208 | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. | Histidine ammonia-lyase. | 0.877 |
FTCD | UROC1 | ENSP00000380856 | ENSP00000373073 | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. | Urocanate hydratase 1. | 0.780 |
HAL | AMDHD1 | ENSP00000261208 | ENSP00000266736 | Histidine ammonia-lyase. | Probable imidazolonepropionase; Amidohydrolase domain containing 1. | 0.969 |
HAL | FTCD | ENSP00000261208 | ENSP00000380856 | Histidine ammonia-lyase. | Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool; In the N-terminal section; belongs to the formiminotransferase family. | 0.877 |