| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLPB | RNF113B | ENSP00000294053 | ENSP00000267291 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | Ring finger protein 113B. | 0.403 |
| CYB5D1 | NME8 | ENSP00000331479 | ENSP00000199447 | Cytochrome b5 domain containing 1. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. | 0.454 |
| CYB5D1 | RNF113B | ENSP00000331479 | ENSP00000267291 | Cytochrome b5 domain containing 1. | Ring finger protein 113B. | 0.408 |
| DCAF12 | RNF113B | ENSP00000355114 | ENSP00000267291 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | Ring finger protein 113B. | 0.408 |
| FARP1 | RNF113B | ENSP00000486285 | ENSP00000267291 | FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). | Ring finger protein 113B. | 0.441 |
| NME8 | CYB5D1 | ENSP00000199447 | ENSP00000331479 | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. | Cytochrome b5 domain containing 1. | 0.454 |
| NME8 | RNF113B | ENSP00000199447 | ENSP00000267291 | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. | Ring finger protein 113B. | 0.425 |
| PIK3C3 | RNF113B | ENSP00000262039 | ENSP00000267291 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] | Ring finger protein 113B. | 0.426 |
| PRPF19 | RNF113B | ENSP00000227524 | ENSP00000267291 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] | Ring finger protein 113B. | 0.433 |
| RNF113B | CLPB | ENSP00000267291 | ENSP00000294053 | Ring finger protein 113B. | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process. | 0.403 |
| RNF113B | CYB5D1 | ENSP00000267291 | ENSP00000331479 | Ring finger protein 113B. | Cytochrome b5 domain containing 1. | 0.408 |
| RNF113B | DCAF12 | ENSP00000267291 | ENSP00000355114 | Ring finger protein 113B. | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. | 0.408 |
| RNF113B | FARP1 | ENSP00000267291 | ENSP00000486285 | Ring finger protein 113B. | FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). | 0.441 |
| RNF113B | NME8 | ENSP00000267291 | ENSP00000199447 | Ring finger protein 113B. | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. | 0.425 |
| RNF113B | PIK3C3 | ENSP00000267291 | ENSP00000262039 | Ring finger protein 113B. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] | 0.426 |
| RNF113B | PRPF19 | ENSP00000267291 | ENSP00000227524 | Ring finger protein 113B. | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and [...] | 0.433 |
| RNF113B | TRIM74 | ENSP00000267291 | ENSP00000285805 | Ring finger protein 113B. | Tripartite motif containing 74; Belongs to the TRIM/RBCC family. | 0.425 |
| TRIM74 | RNF113B | ENSP00000285805 | ENSP00000267291 | Tripartite motif containing 74; Belongs to the TRIM/RBCC family. | Ring finger protein 113B. | 0.425 |
