node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAD2 | ADAT3 | ENSP00000268624 | ENSP00000332448 | Adenosine deaminase domain containing 2. | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily. | 0.504 |
ADAD2 | CBY3 | ENSP00000268624 | ENSP00000366173 | Adenosine deaminase domain containing 2. | Chibby family member 3. | 0.491 |
ADAD2 | FBLL1 | ENSP00000268624 | ENSP00000473383 | Adenosine deaminase domain containing 2. | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | 0.529 |
ADAD2 | HENMT1 | ENSP00000268624 | ENSP00000359049 | Adenosine deaminase domain containing 2. | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. | 0.473 |
ADAD2 | M1AP | ENSP00000268624 | ENSP00000290536 | Adenosine deaminase domain containing 2. | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. | 0.515 |
ADAD2 | MEIOB | ENSP00000268624 | ENSP00000314484 | Adenosine deaminase domain containing 2. | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] | 0.481 |
ADAD2 | RAD21L1 | ENSP00000268624 | ENSP00000386414 | Adenosine deaminase domain containing 2. | Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). | 0.520 |
ADAD2 | SHOC1 | ENSP00000268624 | ENSP00000363405 | Adenosine deaminase domain containing 2. | Protein shortage in chiasmata 1 ortholog; ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures. Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA ; Belongs to the XPF family. Highly divergent. | 0.583 |
ADAD2 | TERB1 | ENSP00000268624 | ENSP00000463762 | Adenosine deaminase domain containing 2. | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] | 0.472 |
ADAD2 | TEX38 | ENSP00000268624 | ENSP00000455854 | Adenosine deaminase domain containing 2. | Testis-expressed protein 38; Testis expressed 38. | 0.476 |
ADAT3 | ADAD2 | ENSP00000332448 | ENSP00000268624 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily. | Adenosine deaminase domain containing 2. | 0.504 |
CBY3 | ADAD2 | ENSP00000366173 | ENSP00000268624 | Chibby family member 3. | Adenosine deaminase domain containing 2. | 0.491 |
CBY3 | MEIOB | ENSP00000366173 | ENSP00000314484 | Chibby family member 3. | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] | 0.421 |
FBLL1 | ADAD2 | ENSP00000473383 | ENSP00000268624 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | Adenosine deaminase domain containing 2. | 0.529 |
FBLL1 | HENMT1 | ENSP00000473383 | ENSP00000359049 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. | 0.463 |
HENMT1 | ADAD2 | ENSP00000359049 | ENSP00000268624 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. | Adenosine deaminase domain containing 2. | 0.473 |
HENMT1 | FBLL1 | ENSP00000359049 | ENSP00000473383 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity). | 0.463 |
M1AP | ADAD2 | ENSP00000290536 | ENSP00000268624 | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. | Adenosine deaminase domain containing 2. | 0.515 |
M1AP | RAD21L1 | ENSP00000290536 | ENSP00000386414 | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. | Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). | 0.478 |
M1AP | SHOC1 | ENSP00000290536 | ENSP00000363405 | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis. | Protein shortage in chiasmata 1 ortholog; ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures. Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA ; Belongs to the XPF family. Highly divergent. | 0.545 |