ADAD2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAD2	ADAT3	ENSP00000268624	ENSP00000332448	Adenosine deaminase domain containing 2.	Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.	0.516
ADAD2	CBY3	ENSP00000268624	ENSP00000366173	Adenosine deaminase domain containing 2.	Chibby family member 3.	0.506
ADAD2	CFAP44	ENSP00000268624	ENSP00000377428	Adenosine deaminase domain containing 2.	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.511
ADAD2	HENMT1	ENSP00000268624	ENSP00000359049	Adenosine deaminase domain containing 2.	Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.	0.504
ADAD2	M1AP	ENSP00000268624	ENSP00000290536	Adenosine deaminase domain containing 2.	Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis.	0.574
ADAD2	RAD21L1	ENSP00000268624	ENSP00000386414	Adenosine deaminase domain containing 2.	Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).	0.581
ADAD2	RNF17	ENSP00000268624	ENSP00000255324	Adenosine deaminase domain containing 2.	RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).	0.498
ADAD2	SHOC1	ENSP00000268624	ENSP00000363405	Adenosine deaminase domain containing 2.	Protein shortage in chiasmata 1 ortholog; ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures. Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA ; Belongs to the XPF family. Highly divergent.	0.618
ADAD2	TERB1	ENSP00000268624	ENSP00000463762	Adenosine deaminase domain containing 2.	Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...]	0.580
ADAD2	TERB2	ENSP00000268624	ENSP00000340644	Adenosine deaminase domain containing 2.	Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...]	0.526
ADAT3	ADAD2	ENSP00000332448	ENSP00000268624	Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.	Adenosine deaminase domain containing 2.	0.516
CBY3	ADAD2	ENSP00000366173	ENSP00000268624	Chibby family member 3.	Adenosine deaminase domain containing 2.	0.506
CFAP44	ADAD2	ENSP00000377428	ENSP00000268624	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Adenosine deaminase domain containing 2.	0.511
CFAP44	RAD21L1	ENSP00000377428	ENSP00000386414	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).	0.523
HENMT1	ADAD2	ENSP00000359049	ENSP00000268624	Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.	Adenosine deaminase domain containing 2.	0.504
HENMT1	TERB1	ENSP00000359049	ENSP00000463762	Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.	Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...]	0.447
HENMT1	TERB2	ENSP00000359049	ENSP00000340644	Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.	Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...]	0.449
M1AP	ADAD2	ENSP00000290536	ENSP00000268624	Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis.	Adenosine deaminase domain containing 2.	0.574
M1AP	RAD21L1	ENSP00000290536	ENSP00000386414	Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis.	Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).	0.550
M1AP	SHOC1	ENSP00000290536	ENSP00000363405	Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis.	Protein shortage in chiasmata 1 ortholog; ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures. Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA ; Belongs to the XPF family. Highly divergent.	0.583