node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APRT | CDK10 | ENSP00000367615 | ENSP00000338673 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) | 0.577 |
APRT | GALNS | ENSP00000367615 | ENSP00000268695 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.774 |
APRT | ZNF276 | ENSP00000367615 | ENSP00000415836 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | Zinc finger protein 276; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.573 |
ARSA | GALNS | ENSP00000216124 | ENSP00000268695 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.869 |
ARSA | GLB1 | ENSP00000216124 | ENSP00000306920 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.651 |
ARSA | IDUA | ENSP00000216124 | ENSP00000247933 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Alpha-L-iduronidase; Iduronidase, alpha-L- | 0.606 |
ARSA | NEU1 | ENSP00000216124 | ENSP00000364782 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Neuraminidase 1; Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage | 0.906 |
ARSA | SUMF1 | ENSP00000216124 | ENSP00000272902 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Formylglycine-generating enzyme; Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family | 0.985 |
CDK10 | APRT | ENSP00000338673 | ENSP00000367615 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.577 |
CDK10 | GALNS | ENSP00000338673 | ENSP00000268695 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.721 |
CDK10 | ZNF276 | ENSP00000338673 | ENSP00000415836 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) | Zinc finger protein 276; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.762 |
CTSA | GALNS | ENSP00000361562 | ENSP00000268695 | Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.961 |
CTSA | GLB1 | ENSP00000361562 | ENSP00000306920 | Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.974 |
CTSA | NEU1 | ENSP00000361562 | ENSP00000364782 | Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Neuraminidase 1; Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage | 0.993 |
GALNS | APRT | ENSP00000268695 | ENSP00000367615 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis | 0.774 |
GALNS | ARSA | ENSP00000268695 | ENSP00000216124 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.869 |
GALNS | CDK10 | ENSP00000268695 | ENSP00000338673 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) | 0.721 |
GALNS | CTSA | ENSP00000268695 | ENSP00000361562 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.961 |
GALNS | GLB1 | ENSP00000268695 | ENSP00000306920 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.984 |
GALNS | GM2A | ENSP00000268695 | ENSP00000349687 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.747 |