| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSA | ARSB | ENSP00000216124 | ENSP00000264914 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | 0.936 |
| ARSA | CTSA | ENSP00000216124 | ENSP00000361562 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.937 |
| ARSA | FUCA1 | ENSP00000216124 | ENSP00000363603 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | 0.928 |
| ARSA | GALNS | ENSP00000216124 | ENSP00000268695 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.977 |
| ARSA | GLA | ENSP00000216124 | ENSP00000218516 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.946 |
| ARSA | GLB1 | ENSP00000216124 | ENSP00000306920 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.952 |
| ARSA | GNS | ENSP00000216124 | ENSP00000258145 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family | 0.925 |
| ARSA | GUSB | ENSP00000216124 | ENSP00000302728 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.954 |
| ARSA | HEXA | ENSP00000216124 | ENSP00000268097 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family | 0.660 |
| ARSB | ARSA | ENSP00000264914 | ENSP00000216124 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.936 |
| ARSB | CTSA | ENSP00000264914 | ENSP00000361562 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.926 |
| ARSB | FUCA1 | ENSP00000264914 | ENSP00000363603 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | 0.917 |
| ARSB | GALNS | ENSP00000264914 | ENSP00000268695 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.933 |
| ARSB | GLA | ENSP00000264914 | ENSP00000218516 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.932 |
| ARSB | GLB1 | ENSP00000264914 | ENSP00000306920 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.928 |
| ARSB | GNS | ENSP00000264914 | ENSP00000258145 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family | 0.937 |
| ARSB | GUSB | ENSP00000264914 | ENSP00000302728 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.962 |
| ARSB | HEXA | ENSP00000264914 | ENSP00000268097 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity; Belongs to the glycosyl hydrolase 20 family | 0.923 |
| ARSB | HYAL4 | ENSP00000264914 | ENSP00000223026 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium. In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity); Belongs to the sulfatase family | Hyaluronidase-4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.929 |
| CTSA | ARSA | ENSP00000361562 | ENSP00000216124 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.937 |
