GALNS protein (human) - STRING interaction network

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Score

GALNS

N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family (522 aa)

Predicted Functional Partners:

GLB1

0.984

CTSA

0.961

SUMF1

0.917

ARSA

0.869

NEU1

0.778

APRT

0.774

GM2A

0.747

IDUA

0.740

CDK10

0.721

ZNF276

0.720

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APRT	CDK10	ENSP00000367615	ENSP00000338673	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)	0.577
APRT	GALNS	ENSP00000367615	ENSP00000268695	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	0.774
APRT	ZNF276	ENSP00000367615	ENSP00000415836	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	Zinc finger protein 276; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.573
ARSA	GALNS	ENSP00000216124	ENSP00000268695	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	0.869
ARSA	GLB1	ENSP00000216124	ENSP00000306920	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family	0.651
ARSA	IDUA	ENSP00000216124	ENSP00000247933	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Alpha-L-iduronidase; Iduronidase, alpha-L-	0.606
ARSA	NEU1	ENSP00000216124	ENSP00000364782	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Neuraminidase 1; Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage	0.906
ARSA	SUMF1	ENSP00000216124	ENSP00000272902	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	Formylglycine-generating enzyme; Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family	0.985
CDK10	APRT	ENSP00000338673	ENSP00000367615	Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	0.577
CDK10	GALNS	ENSP00000338673	ENSP00000268695	Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	0.721
CDK10	ZNF276	ENSP00000338673	ENSP00000415836	Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)	Zinc finger protein 276; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.762
CTSA	GALNS	ENSP00000361562	ENSP00000268695	Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	0.961
CTSA	GLB1	ENSP00000361562	ENSP00000306920	Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family	0.974
CTSA	NEU1	ENSP00000361562	ENSP00000364782	Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins	Neuraminidase 1; Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage	0.993
GALNS	APRT	ENSP00000268695	ENSP00000367615	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	0.774
GALNS	ARSA	ENSP00000268695	ENSP00000216124	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family	0.869
GALNS	CDK10	ENSP00000268695	ENSP00000338673	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells)	0.721
GALNS	CTSA	ENSP00000268695	ENSP00000361562	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	Cathepsin a (carboxypeptidase c); Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins	0.961
GALNS	GLB1	ENSP00000268695	ENSP00000306920	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family	0.984
GALNS	GM2A	ENSP00000268695	ENSP00000349687	N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family	Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3	0.747