node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENKD1 | GFOD2 | ENSP00000243878 | ENSP00000268797 | Enkurin domain containing 1. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.760 |
GALK2 | GFOD1 | ENSP00000453129 | ENSP00000368589 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily. | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | 0.491 |
GALK2 | GFOD2 | ENSP00000453129 | ENSP00000268797 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.505 |
GALK2 | TGDS | ENSP00000453129 | ENSP00000261296 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily. | TDP-glucose 4,6-dehydratase. | 0.593 |
GFOD1 | GALK2 | ENSP00000368589 | ENSP00000453129 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily. | 0.491 |
GFOD1 | GFOD2 | ENSP00000368589 | ENSP00000268797 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.784 |
GFOD1 | KARS1 | ENSP00000368589 | ENSP00000325448 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | 0.625 |
GFOD1 | NKIRAS2 | ENSP00000368589 | ENSP00000303580 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. | 0.784 |
GFOD1 | NMNAT1 | ENSP00000368589 | ENSP00000366410 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.498 |
GFOD1 | RGN | ENSP00000368589 | ENSP00000380365 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)- dependent cellular processes and enzyme activities (By similarity). | 0.699 |
GFOD1 | SORD | ENSP00000368589 | ENSP00000267814 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with D- sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D- xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as d [...] | 0.532 |
GFOD1 | TGDS | ENSP00000368589 | ENSP00000261296 | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | TDP-glucose 4,6-dehydratase. | 0.724 |
GFOD2 | ENKD1 | ENSP00000268797 | ENSP00000243878 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Enkurin domain containing 1. | 0.760 |
GFOD2 | GALK2 | ENSP00000268797 | ENSP00000453129 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates; Belongs to the GHMP kinase family. GalK subfamily. | 0.505 |
GFOD2 | GFOD1 | ENSP00000268797 | ENSP00000368589 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. | 0.784 |
GFOD2 | KARS1 | ENSP00000268797 | ENSP00000325448 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. | 0.625 |
GFOD2 | NKIRAS2 | ENSP00000268797 | ENSP00000303580 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. | 0.797 |
GFOD2 | NMNAT1 | ENSP00000268797 | ENSP00000366410 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.625 |
GFOD2 | RGN | ENSP00000268797 | ENSP00000380365 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)- dependent cellular processes and enzyme activities (By similarity). | 0.699 |
GFOD2 | SORD | ENSP00000268797 | ENSP00000267814 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with D- sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D- xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as d [...] | 0.532 |