GFOD2 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH18A1	GFOD1	ENSP00000360268	ENSP00000368589	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	0.557
ALDH18A1	GFOD2	ENSP00000360268	ENSP00000268797	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	0.557
ALDH18A1	KARS1	ENSP00000360268	ENSP00000325448	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.	0.467
ALDH18A1	NMNAT1	ENSP00000360268	ENSP00000366410	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...]	0.535
ALDH18A1	NMNAT3	ENSP00000360268	ENSP00000495112	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	Nicotinamide nucleotide adenylyltransferase 3.	0.535
ENKD1	GFOD2	ENSP00000243878	ENSP00000268797	Enkurin domain containing 1.	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	0.708
GFOD1	ALDH18A1	ENSP00000368589	ENSP00000360268	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	0.557
GFOD1	GFOD2	ENSP00000368589	ENSP00000268797	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	0.999
GFOD1	KARS1	ENSP00000368589	ENSP00000325448	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.	0.586
GFOD1	NKIRAS2	ENSP00000368589	ENSP00000303580	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	0.999
GFOD1	NMNAT1	ENSP00000368589	ENSP00000366410	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...]	0.512
GFOD1	NMNAT3	ENSP00000368589	ENSP00000495112	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	Nicotinamide nucleotide adenylyltransferase 3.	0.424
GFOD1	RGN	ENSP00000368589	ENSP00000380365	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)- dependent cellular processes and enzyme activities (By similarity).	0.588
GFOD2	ALDH18A1	ENSP00000268797	ENSP00000360268	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.	0.557
GFOD2	ENKD1	ENSP00000268797	ENSP00000243878	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	Enkurin domain containing 1.	0.708
GFOD2	GFOD1	ENSP00000268797	ENSP00000368589	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.	0.999
GFOD2	KARS1	ENSP00000268797	ENSP00000325448	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.	0.586
GFOD2	NKIRAS2	ENSP00000268797	ENSP00000303580	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.	0.999
GFOD2	NMNAT1	ENSP00000268797	ENSP00000366410	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...]	0.540
GFOD2	NMNAT3	ENSP00000268797	ENSP00000495112	Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.	Nicotinamide nucleotide adenylyltransferase 3.	0.502