node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFAP161 | CFAP57 | ENSP00000286732 | ENSP00000479773 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Cilia and flagella associated protein 57. | 0.501 |
CFAP161 | LRRC46 | ENSP00000286732 | ENSP00000269025 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | 0.674 |
CFAP161 | TSNAXIP1 | ENSP00000286732 | ENSP00000457241 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis. | 0.553 |
CFAP57 | CFAP161 | ENSP00000479773 | ENSP00000286732 | Cilia and flagella associated protein 57. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.501 |
CFAP57 | LRRC46 | ENSP00000479773 | ENSP00000269025 | Cilia and flagella associated protein 57. | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | 0.611 |
CFAP57 | TSNAXIP1 | ENSP00000479773 | ENSP00000457241 | Cilia and flagella associated protein 57. | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis. | 0.561 |
LRRC46 | CFAP161 | ENSP00000269025 | ENSP00000286732 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. | 0.674 |
LRRC46 | CFAP57 | ENSP00000269025 | ENSP00000479773 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Cilia and flagella associated protein 57. | 0.611 |
LRRC46 | PACS2 | ENSP00000269025 | ENSP00000393559 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinc [...] | 0.742 |
LRRC46 | POLE | ENSP00000269025 | ENSP00000322570 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | DNA polymerase epsilon catalytic subunit A; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair. Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) [...] | 0.614 |
LRRC46 | PPP1CA | ENSP00000269025 | ENSP00000326031 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.572 |
LRRC46 | PPP1CC | ENSP00000269025 | ENSP00000341779 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | 0.575 |
LRRC46 | PPP1R3D | ENSP00000269025 | ENSP00000360035 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Protein phosphatase 1 regulatory subunit 3D; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. | 0.567 |
LRRC46 | RIBC1 | ENSP00000269025 | ENSP00000364476 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family. | 0.566 |
LRRC46 | TSNAXIP1 | ENSP00000269025 | ENSP00000457241 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis. | 0.621 |
LRRC46 | ZMYND10 | ENSP00000269025 | ENSP00000231749 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity). Belongs to the ZMYND10 family. | 0.663 |
PACS2 | LRRC46 | ENSP00000393559 | ENSP00000269025 | Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinc [...] | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | 0.742 |
POLE | LRRC46 | ENSP00000322570 | ENSP00000269025 | DNA polymerase epsilon catalytic subunit A; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair. Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) [...] | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | 0.614 |
PPP1CA | LRRC46 | ENSP00000326031 | ENSP00000269025 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46. | 0.572 |
PPP1CA | PPP1CC | ENSP00000326031 | ENSP00000341779 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | 0.998 |