node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL5C | GBF1 | ENSP00000269586 | ENSP00000359000 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), a [...] | 0.477 |
ARL5C | GTF3C5 | ENSP00000269586 | ENSP00000361180 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. | 0.400 |
ARL5C | ITSN1 | ENSP00000269586 | ENSP00000370719 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | 0.535 |
ARL5C | ITSN2 | ENSP00000269586 | ENSP00000347244 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.536 |
ARL5C | OR4M2 | ENSP00000269586 | ENSP00000483239 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Olfactory receptor 4M2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.400 |
ARL5C | OR5D13 | ENSP00000269586 | ENSP00000485428 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Olfactory receptor 5D13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.447 |
ARL5C | VPS54 | ENSP00000269586 | ENSP00000272322 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling ; Belongs to the VPS54 family. | 0.438 |
ARL5C | VWA5B1 | ENSP00000269586 | ENSP00000364220 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Von Willebrand factor A domain containing 5B1. | 0.498 |
ARL5C | WDR89 | ENSP00000269586 | ENSP00000378399 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | WD repeat domain 89. | 0.430 |
GBF1 | ARL5C | ENSP00000359000 | ENSP00000269586 | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), a [...] | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.477 |
GTF3C5 | ARL5C | ENSP00000361180 | ENSP00000269586 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.400 |
ITSN1 | ARL5C | ENSP00000370719 | ENSP00000269586 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.535 |
ITSN1 | ITSN2 | ENSP00000370719 | ENSP00000347244 | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.664 |
ITSN2 | ARL5C | ENSP00000347244 | ENSP00000269586 | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.536 |
ITSN2 | ITSN1 | ENSP00000347244 | ENSP00000370719 | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex. Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits. Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (By similarity). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); inter [...] | 0.664 |
OR4M2 | ARL5C | ENSP00000483239 | ENSP00000269586 | Olfactory receptor 4M2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.400 |
OR5D13 | ARL5C | ENSP00000485428 | ENSP00000269586 | Olfactory receptor 5D13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.447 |
VPS54 | ARL5C | ENSP00000272322 | ENSP00000269586 | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling ; Belongs to the VPS54 family. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.438 |
VWA5B1 | ARL5C | ENSP00000364220 | ENSP00000269586 | Von Willebrand factor A domain containing 5B1. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.498 |
WDR89 | ARL5C | ENSP00000378399 | ENSP00000269586 | WD repeat domain 89. | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.430 |