node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NDEL1 | ZNF544 | ENSP00000333982 | ENSP00000269829 | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | Zinc finger protein 544; May be involved in transcriptional regulation. | 0.519 |
PAAF1 | WDR73 | ENSP00000438071 | ENSP00000387982 | Proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation; Belongs to the WD repeat PAAF1/RPN14 family. | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics. | 0.444 |
PAAF1 | ZNF544 | ENSP00000438071 | ENSP00000269829 | Proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation; Belongs to the WD repeat PAAF1/RPN14 family. | Zinc finger protein 544; May be involved in transcriptional regulation. | 0.507 |
PEX2 | ZNF544 | ENSP00000349543 | ENSP00000269829 | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | Zinc finger protein 544; May be involved in transcriptional regulation. | 0.438 |
TRIM28 | ZNF544 | ENSP00000253024 | ENSP00000269829 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 544; May be involved in transcriptional regulation. | 0.628 |
TSTD2 | ZNF544 | ENSP00000342499 | ENSP00000269829 | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2; Thiosulfate sulfurtransferase like domain containing 2. | Zinc finger protein 544; May be involved in transcriptional regulation. | 0.400 |
WDR73 | PAAF1 | ENSP00000387982 | ENSP00000438071 | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics. | Proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation; Belongs to the WD repeat PAAF1/RPN14 family. | 0.444 |
WDR73 | ZNF544 | ENSP00000387982 | ENSP00000269829 | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics. | Zinc finger protein 544; May be involved in transcriptional regulation. | 0.400 |
ZNF544 | NDEL1 | ENSP00000269829 | ENSP00000333982 | Zinc finger protein 544; May be involved in transcriptional regulation. | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] | 0.519 |
ZNF544 | PAAF1 | ENSP00000269829 | ENSP00000438071 | Zinc finger protein 544; May be involved in transcriptional regulation. | Proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation; Belongs to the WD repeat PAAF1/RPN14 family. | 0.507 |
ZNF544 | PEX2 | ENSP00000269829 | ENSP00000349543 | Zinc finger protein 544; May be involved in transcriptional regulation. | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family. | 0.438 |
ZNF544 | TRIM28 | ENSP00000269829 | ENSP00000253024 | Zinc finger protein 544; May be involved in transcriptional regulation. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.628 |
ZNF544 | TSTD2 | ENSP00000269829 | ENSP00000342499 | Zinc finger protein 544; May be involved in transcriptional regulation. | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2; Thiosulfate sulfurtransferase like domain containing 2. | 0.400 |
ZNF544 | WDR73 | ENSP00000269829 | ENSP00000387982 | Zinc finger protein 544; May be involved in transcriptional regulation. | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics. | 0.400 |