node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2orf83 | C8orf86 | ENSP00000493351 | ENSP00000350856 | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86. | 0.630 |
C2orf83 | DAND5 | ENSP00000493351 | ENSP00000323155 | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). Belongs to the DAN family. | 0.467 |
C2orf83 | TERB1 | ENSP00000493351 | ENSP00000463762 | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] | 0.455 |
C2orf83 | ZIM3 | ENSP00000493351 | ENSP00000269834 | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.451 |
C2orf83 | ZNF716 | ENSP00000493351 | ENSP00000394248 | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | Zinc finger protein 716; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.495 |
C8orf86 | C2orf83 | ENSP00000350856 | ENSP00000493351 | Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86. | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | 0.630 |
C8orf86 | ZIM3 | ENSP00000350856 | ENSP00000269834 | Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86. | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.436 |
C8orf86 | ZNF716 | ENSP00000350856 | ENSP00000394248 | Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86. | Zinc finger protein 716; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.436 |
DAND5 | C2orf83 | ENSP00000323155 | ENSP00000493351 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). Belongs to the DAN family. | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | 0.467 |
DAND5 | ZIM3 | ENSP00000323155 | ENSP00000269834 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). Belongs to the DAN family. | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.432 |
FBXL4 | ZIM3 | ENSP00000358247 | ENSP00000269834 | F-box and leucine rich repeat protein 4. | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.409 |
IGF2R | ZIM3 | ENSP00000349437 | ENSP00000269834 | Cation-independent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.452 |
TERB1 | C2orf83 | ENSP00000463762 | ENSP00000493351 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83. | 0.455 |
TERB1 | ZIM3 | ENSP00000463762 | ENSP00000269834 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.455 |
TRIM28 | ZIM2 | ENSP00000253024 | ENSP00000486502 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.634 |
TRIM28 | ZIM3 | ENSP00000253024 | ENSP00000269834 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.625 |
TRIM28 | ZNF716 | ENSP00000253024 | ENSP00000394248 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 716; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
USP29 | ZIM2 | ENSP00000254181 | ENSP00000486502 | Ubiquitin specific peptidase 29. | Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.675 |
USP29 | ZIM3 | ENSP00000254181 | ENSP00000269834 | Ubiquitin specific peptidase 29. | Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.720 |
ZIM2 | TRIM28 | ENSP00000486502 | ENSP00000253024 | Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.634 |