node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFL1 | HUNK | ENSP00000432660 | ENSP00000270112 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). | Hormonally up-regulated Neu-associated kinase. | 0.442 |
CFL1 | MYC | ENSP00000432660 | ENSP00000478887 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.706 |
EVA1C | HUNK | ENSP00000300255 | ENSP00000270112 | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family. | Hormonally up-regulated Neu-associated kinase. | 0.413 |
EVA1C | URB1 | ENSP00000300255 | ENSP00000372199 | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family. | Nucleolar pre-ribosomal-associated protein 1; URB1 ribosome biogenesis homolog. | 0.587 |
HUNK | CFL1 | ENSP00000270112 | ENSP00000432660 | Hormonally up-regulated Neu-associated kinase. | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). | 0.442 |
HUNK | EVA1C | ENSP00000270112 | ENSP00000300255 | Hormonally up-regulated Neu-associated kinase. | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family. | 0.413 |
HUNK | MIS18A | ENSP00000270112 | ENSP00000290130 | Hormonally up-regulated Neu-associated kinase. | Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. | 0.483 |
HUNK | MYC | ENSP00000270112 | ENSP00000478887 | Hormonally up-regulated Neu-associated kinase. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.503 |
HUNK | RABEP1 | ENSP00000270112 | ENSP00000445408 | Hormonally up-regulated Neu-associated kinase. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). Belongs to the rabaptin family. | 0.600 |
HUNK | SCAF4 | ENSP00000270112 | ENSP00000286835 | Hormonally up-regulated Neu-associated kinase. | SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | 0.480 |
HUNK | SYNJ1 | ENSP00000270112 | ENSP00000409667 | Hormonally up-regulated Neu-associated kinase. | Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). Belongs to the synaptojanin family. | 0.519 |
HUNK | TRAPPC1 | ENSP00000270112 | ENSP00000302783 | Hormonally up-regulated Neu-associated kinase. | Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily. | 0.591 |
HUNK | URB1 | ENSP00000270112 | ENSP00000372199 | Hormonally up-regulated Neu-associated kinase. | Nucleolar pre-ribosomal-associated protein 1; URB1 ribosome biogenesis homolog. | 0.551 |
HUNK | ZBTB21 | ENSP00000270112 | ENSP00000308759 | Hormonally up-regulated Neu-associated kinase. | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor. | 0.442 |
MIS18A | HUNK | ENSP00000290130 | ENSP00000270112 | Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. | Hormonally up-regulated Neu-associated kinase. | 0.483 |
MIS18A | URB1 | ENSP00000290130 | ENSP00000372199 | Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. | Nucleolar pre-ribosomal-associated protein 1; URB1 ribosome biogenesis homolog. | 0.563 |
MYC | CFL1 | ENSP00000478887 | ENSP00000432660 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). | 0.706 |
MYC | HUNK | ENSP00000478887 | ENSP00000270112 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | Hormonally up-regulated Neu-associated kinase. | 0.503 |
RABEP1 | HUNK | ENSP00000445408 | ENSP00000270112 | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). Belongs to the rabaptin family. | Hormonally up-regulated Neu-associated kinase. | 0.600 |
SCAF4 | HUNK | ENSP00000286835 | ENSP00000270112 | SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently [...] | Hormonally up-regulated Neu-associated kinase. | 0.480 |