node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC6 | ARMC7 | ENSP00000444156 | ENSP00000245543 | Armadillo repeat containing 6. | Armadillo repeat containing 7. | 0.477 |
ARMC6 | KLHDC4 | ENSP00000444156 | ENSP00000270583 | Armadillo repeat containing 6. | Kelch domain containing 4. | 0.539 |
ARMC7 | ARMC6 | ENSP00000245543 | ENSP00000444156 | Armadillo repeat containing 7. | Armadillo repeat containing 6. | 0.477 |
ARMC7 | KLHDC4 | ENSP00000245543 | ENSP00000270583 | Armadillo repeat containing 7. | Kelch domain containing 4. | 0.451 |
CEBPZ | KLHDC4 | ENSP00000234170 | ENSP00000270583 | CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family. | Kelch domain containing 4. | 0.519 |
CEBPZ | UTP6 | ENSP00000234170 | ENSP00000261708 | CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family. | U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family. | 0.832 |
CROT | KLHDC4 | ENSP00000413575 | ENSP00000270583 | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. | Kelch domain containing 4. | 0.623 |
KLHDC4 | ARMC6 | ENSP00000270583 | ENSP00000444156 | Kelch domain containing 4. | Armadillo repeat containing 6. | 0.539 |
KLHDC4 | ARMC7 | ENSP00000270583 | ENSP00000245543 | Kelch domain containing 4. | Armadillo repeat containing 7. | 0.451 |
KLHDC4 | CEBPZ | ENSP00000270583 | ENSP00000234170 | Kelch domain containing 4. | CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family. | 0.519 |
KLHDC4 | CROT | ENSP00000270583 | ENSP00000413575 | Kelch domain containing 4. | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester. | 0.623 |
KLHDC4 | L3MBTL2 | ENSP00000270583 | ENSP00000216237 | Kelch domain containing 4. | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. | 0.436 |
KLHDC4 | PRDM15 | ENSP00000270583 | ENSP00000269844 | Kelch domain containing 4. | PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] | 0.450 |
KLHDC4 | SHCBP1 | ENSP00000270583 | ENSP00000306473 | Kelch domain containing 4. | SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. | 0.457 |
KLHDC4 | TRAPPC2L | ENSP00000270583 | ENSP00000457728 | Kelch domain containing 4. | Trafficking protein particle complex subunit 2-like protein; Plays a role in vesicular transport from endoplasmic reticulum to Golgi. | 0.437 |
KLHDC4 | UTP6 | ENSP00000270583 | ENSP00000261708 | Kelch domain containing 4. | U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family. | 0.538 |
KLHDC4 | ZCCHC14 | ENSP00000270583 | ENSP00000268616 | Kelch domain containing 4. | Zinc finger CCHC-type containing 14. | 0.468 |
L3MBTL2 | KLHDC4 | ENSP00000216237 | ENSP00000270583 | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. | Kelch domain containing 4. | 0.436 |
PRDM15 | KLHDC4 | ENSP00000269844 | ENSP00000270583 | PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] | Kelch domain containing 4. | 0.450 |
SHCBP1 | KLHDC4 | ENSP00000306473 | ENSP00000270583 | SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells. | Kelch domain containing 4. | 0.457 |