MOB3C protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C18orf21	MOB3C	ENSP00000465517	ENSP00000271139	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	0.740
C18orf21	NEPRO	ENSP00000465517	ENSP00000320251	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.	0.995
C18orf21	POP4	ENSP00000465517	ENSP00000465213	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.999
C18orf21	RPP25	ENSP00000465517	ENSP00000317691	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.999
C18orf21	RPP30	ENSP00000465517	ENSP00000389182	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Ribonuclease P protein subunit p30; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.995
C18orf21	RPP38	ENSP00000465517	ENSP00000478982	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	Ribonuclease P protein subunit p38; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre- rRNA sequences. Belongs to the eukaryotic ribosomal protein eL8 family.	0.999
CMTM3	MOB3C	ENSP00000400482	ENSP00000271139	CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family.	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	0.620
LATS1	MOB3C	ENSP00000437550	ENSP00000271139	Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...]	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	0.605
LATS1	MOB4	ENSP00000437550	ENSP00000315702	Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...]	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family.	0.671
MOB3C	C18orf21	ENSP00000271139	ENSP00000465517	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.	0.740
MOB3C	CMTM3	ENSP00000271139	ENSP00000400482	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family.	0.620
MOB3C	LATS1	ENSP00000271139	ENSP00000437550	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...]	0.605
MOB3C	MOB4	ENSP00000271139	ENSP00000315702	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family.	0.643
MOB3C	NEPRO	ENSP00000271139	ENSP00000320251	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.	0.727
MOB3C	POP4	ENSP00000271139	ENSP00000465213	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.610
MOB3C	RPP25	ENSP00000271139	ENSP00000317691	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.663
MOB3C	RPP30	ENSP00000271139	ENSP00000389182	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Ribonuclease P protein subunit p30; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.624
MOB3C	RPP38	ENSP00000271139	ENSP00000478982	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Ribonuclease P protein subunit p38; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre- rRNA sequences. Belongs to the eukaryotic ribosomal protein eL8 family.	0.706
MOB3C	ZBTB10	ENSP00000271139	ENSP00000387462	MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.	Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.	0.600
MOB4	LATS1	ENSP00000315702	ENSP00000437550	MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family.	Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...]	0.671