node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKDD1B | MOB3C | ENSP00000471417 | ENSP00000271139 | Ankyrin repeat and death domain containing 1B. | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | 0.535 |
CMTM3 | MOB3C | ENSP00000400482 | ENSP00000271139 | CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family. | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | 0.464 |
DPH5 | MOB3C | ENSP00000359127 | ENSP00000271139 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | 0.493 |
DPH5 | NAA20 | ENSP00000359127 | ENSP00000335636 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. | N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily. | 0.460 |
LATS1 | MOB3C | ENSP00000437550 | ENSP00000271139 | Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...] | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | 0.494 |
LATS1 | MOB4 | ENSP00000437550 | ENSP00000315702 | Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...] | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | 0.565 |
MOB3C | ANKDD1B | ENSP00000271139 | ENSP00000471417 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Ankyrin repeat and death domain containing 1B. | 0.535 |
MOB3C | CMTM3 | ENSP00000271139 | ENSP00000400482 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family. | 0.464 |
MOB3C | DPH5 | ENSP00000271139 | ENSP00000359127 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.493 |
MOB3C | LATS1 | ENSP00000271139 | ENSP00000437550 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...] | 0.494 |
MOB3C | MOB4 | ENSP00000271139 | ENSP00000315702 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | 0.663 |
MOB3C | MYADML2 | ENSP00000271139 | ENSP00000386702 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2. | 0.504 |
MOB3C | NAA20 | ENSP00000271139 | ENSP00000335636 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration; Belongs to the acetyltransferase family. ARD1 subfamily. | 0.491 |
MOB3C | OR2T12 | ENSP00000271139 | ENSP00000493000 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Olfactory receptor 2T12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.474 |
MOB3C | STK38 | ENSP00000271139 | ENSP00000229812 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. | 0.510 |
MOB3C | TMEM218 | ENSP00000271139 | ENSP00000436596 | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | Transmembrane protein 218; May be involved in ciliary biogenesis or function. | 0.466 |
MOB4 | LATS1 | ENSP00000315702 | ENSP00000437550 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus [...] | 0.565 |
MOB4 | MOB3C | ENSP00000315702 | ENSP00000271139 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | 0.663 |
MOB4 | STK38 | ENSP00000315702 | ENSP00000229812 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family. | Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. | 0.673 |
MYADML2 | MOB3C | ENSP00000386702 | ENSP00000271139 | Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2. | MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family. | 0.504 |