node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP5PD | MDH2 | ENSP00000301587 | ENSP00000327070 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | 0.724 |
ATP5PD | MPC2 | ENSP00000301587 | ENSP00000271373 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.572 |
ATP5PD | NDUFA6 | ENSP00000301587 | ENSP00000482543 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.947 |
ATP5PD | NDUFS4 | ENSP00000301587 | ENSP00000296684 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.957 |
ATP5PD | VDAC1 | ENSP00000301587 | ENSP00000378487 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] | 0.735 |
FLOT2 | MPC2 | ENSP00000378368 | ENSP00000271373 | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.501 |
MDH2 | ATP5PD | ENSP00000327070 | ENSP00000301587 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | 0.724 |
MDH2 | MPC2 | ENSP00000327070 | ENSP00000271373 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.539 |
MDH2 | PC | ENSP00000327070 | ENSP00000498994 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.986 |
MDH2 | VDAC1 | ENSP00000327070 | ENSP00000378487 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] | 0.751 |
MPC1 | MPC2 | ENSP00000354223 | ENSP00000271373 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.999 |
MPC1 | PC | ENSP00000354223 | ENSP00000498994 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. | 0.428 |
MPC1L | MPC2 | ENSP00000489748 | ENSP00000271373 | Mitochondrial pyruvate carrier 1 like. | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | 0.884 |
MPC2 | ATP5PD | ENSP00000271373 | ENSP00000301587 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] | 0.572 |
MPC2 | FLOT2 | ENSP00000271373 | ENSP00000378368 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily. | 0.501 |
MPC2 | MDH2 | ENSP00000271373 | ENSP00000327070 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. | 0.539 |
MPC2 | MPC1 | ENSP00000271373 | ENSP00000354223 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. | 0.999 |
MPC2 | MPC1L | ENSP00000271373 | ENSP00000489748 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | Mitochondrial pyruvate carrier 1 like. | 0.884 |
MPC2 | NDUFA6 | ENSP00000271373 | ENSP00000482543 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.635 |
MPC2 | NDUFS4 | ENSP00000271373 | ENSP00000296684 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.618 |