node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNG1 | CAPN9 | ENSP00000226021 | ENSP00000271971 | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.515 |
CACNG1 | PDLIM3 | ENSP00000226021 | ENSP00000284767 | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells. | 0.570 |
CAPN8 | CAPN9 | ENSP00000355837 | ENSP00000271971 | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family. | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.553 |
CAPN8 | CAPNS1 | ENSP00000355837 | ENSP00000464849 | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.677 |
CAPN8 | CAPNS2 | ENSP00000355837 | ENSP00000400882 | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.668 |
CAPN8 | CAST | ENSP00000355837 | ENSP00000422176 | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.955 |
CAPN9 | CACNG1 | ENSP00000271971 | ENSP00000226021 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. | 0.515 |
CAPN9 | CAPN8 | ENSP00000271971 | ENSP00000355837 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family. | 0.553 |
CAPN9 | CAPNS1 | ENSP00000271971 | ENSP00000464849 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.677 |
CAPN9 | CAPNS2 | ENSP00000271971 | ENSP00000400882 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.663 |
CAPN9 | CAST | ENSP00000271971 | ENSP00000422176 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.768 |
CAPN9 | CWH43 | ENSP00000271971 | ENSP00000226432 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. | 0.510 |
CAPN9 | CYP2F1 | ENSP00000271971 | ENSP00000333534 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Cytochrome P450 2F1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Belongs to the cytochrome P450 family. | 0.473 |
CAPN9 | GKN1 | ENSP00000271971 | ENSP00000501093 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. | 0.945 |
CAPN9 | PDLIM3 | ENSP00000271971 | ENSP00000284767 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells. | 0.493 |
CAPN9 | SUSD1 | ENSP00000271971 | ENSP00000363382 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Sushi domain containing 1. | 0.529 |
CAPNS1 | CAPN8 | ENSP00000464849 | ENSP00000355837 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family. | 0.677 |
CAPNS1 | CAPN9 | ENSP00000464849 | ENSP00000271971 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.677 |
CAPNS1 | CAPNS2 | ENSP00000464849 | ENSP00000400882 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. | 0.885 |
CAPNS1 | CAST | ENSP00000464849 | ENSP00000422176 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.995 |