node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAV1 | CD59 | ENSP00000339191 | ENSP00000498879 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recrui [...] | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | 0.842 |
CAV1 | MALL | ENSP00000339191 | ENSP00000272462 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recrui [...] | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | 0.702 |
CD59 | CAV1 | ENSP00000498879 | ENSP00000339191 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recrui [...] | 0.842 |
CD59 | MAL2 | ENSP00000498879 | ENSP00000479708 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. | 0.660 |
CD59 | MALL | ENSP00000498879 | ENSP00000272462 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | 0.696 |
CD59 | TPD52 | ENSP00000498879 | ENSP00000429309 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | Tumor protein D52; Belongs to the TPD52 family. | 0.609 |
MAL2 | CD59 | ENSP00000479708 | ENSP00000498879 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | 0.660 |
MAL2 | MALL | ENSP00000479708 | ENSP00000272462 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | 0.490 |
MAL2 | TPD52 | ENSP00000479708 | ENSP00000429309 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. | Tumor protein D52; Belongs to the TPD52 family. | 0.948 |
MAL2 | TPD52L2 | ENSP00000479708 | ENSP00000217121 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. | Tumor protein D54; TPD52 like 2. | 0.924 |
MALL | CAV1 | ENSP00000272462 | ENSP00000339191 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recrui [...] | 0.702 |
MALL | CD59 | ENSP00000272462 | ENSP00000498879 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. | 0.696 |
MALL | MAL2 | ENSP00000272462 | ENSP00000479708 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. | 0.490 |
MALL | MYADML2 | ENSP00000272462 | ENSP00000386702 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2. | 0.519 |
MALL | NPHP1 | ENSP00000272462 | ENSP00000313169 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina dev [...] | 0.946 |
MALL | PLLP | ENSP00000272462 | ENSP00000219207 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family. | 0.684 |
MALL | RGPD5 | ENSP00000272462 | ENSP00000016946 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | RANBP2-like and GRIP domain-containing protein 5/6; RANBP2 like and GRIP domain containing 5. | 0.582 |
MALL | RGPD6 | ENSP00000272462 | ENSP00000330842 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | RANBP2 like and GRIP domain containing 6. | 0.606 |
MALL | TPD52 | ENSP00000272462 | ENSP00000429309 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Tumor protein D52; Belongs to the TPD52 family. | 0.549 |
MALL | TPD52L2 | ENSP00000272462 | ENSP00000217121 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family. | Tumor protein D54; TPD52 like 2. | 0.812 |