AMMECR1L protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMMECR1	AMMECR1L	ENSP00000262844	ENSP00000272647	AMMECR nuclear protein 1.	AMMECR1-like protein; AMMECR1 like.	0.714
AMMECR1L	AMMECR1	ENSP00000272647	ENSP00000262844	AMMECR1-like protein; AMMECR1 like.	AMMECR nuclear protein 1.	0.714
AMMECR1L	DDX50	ENSP00000272647	ENSP00000362687	AMMECR1-like protein; AMMECR1 like.	ATP-dependent RNA helicase DDX50; DExD-box helicase 50.	0.656
AMMECR1L	FGL1	ENSP00000272647	ENSP00000381133	AMMECR1-like protein; AMMECR1 like.	Fibrinogen-like protein 1; Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.	0.789
AMMECR1L	FNTA	ENSP00000272647	ENSP00000303423	AMMECR1-like protein; AMMECR1 like.	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.	0.911
AMMECR1L	GPATCH3	ENSP00000272647	ENSP00000354645	AMMECR1-like protein; AMMECR1 like.	G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.	0.666
AMMECR1L	MACF1	ENSP00000272647	ENSP00000354573	AMMECR1-like protein; AMMECR1 like.	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling [...]	0.668
AMMECR1L	MTMR14	ENSP00000272647	ENSP00000296003	AMMECR1-like protein; AMMECR1 like.	Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.	0.648
AMMECR1L	PGGT1B	ENSP00000272647	ENSP00000404676	AMMECR1-like protein; AMMECR1 like.	Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.	0.999
AMMECR1L	TLK2	ENSP00000272647	ENSP00000316512	AMMECR1-like protein; AMMECR1 like.	Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	0.628
AMMECR1L	TMUB2	ENSP00000272647	ENSP00000444565	AMMECR1-like protein; AMMECR1 like.	Transmembrane and ubiquitin like domain containing 2.	0.649
DDX50	AMMECR1L	ENSP00000362687	ENSP00000272647	ATP-dependent RNA helicase DDX50; DExD-box helicase 50.	AMMECR1-like protein; AMMECR1 like.	0.656
DDX50	GPATCH3	ENSP00000362687	ENSP00000354645	ATP-dependent RNA helicase DDX50; DExD-box helicase 50.	G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.	0.588
DDX50	MTMR14	ENSP00000362687	ENSP00000296003	ATP-dependent RNA helicase DDX50; DExD-box helicase 50.	Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.	0.509
DDX50	TLK2	ENSP00000362687	ENSP00000316512	ATP-dependent RNA helicase DDX50; DExD-box helicase 50.	Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.	0.627
DDX50	TMUB2	ENSP00000362687	ENSP00000444565	ATP-dependent RNA helicase DDX50; DExD-box helicase 50.	Transmembrane and ubiquitin like domain containing 2.	0.565
FGL1	AMMECR1L	ENSP00000381133	ENSP00000272647	Fibrinogen-like protein 1; Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.	AMMECR1-like protein; AMMECR1 like.	0.789
FNTA	AMMECR1L	ENSP00000303423	ENSP00000272647	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.	AMMECR1-like protein; AMMECR1 like.	0.911
FNTA	PGGT1B	ENSP00000303423	ENSP00000404676	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.	Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.	0.999
GPATCH3	AMMECR1L	ENSP00000354645	ENSP00000272647	G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.	AMMECR1-like protein; AMMECR1 like.	0.666