| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASIC4 | PNKD | ENSP00000326627 | ENSP00000273077 | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity; Acid sensing ion channel subunits | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.905 |
| ATP1A3 | PNKD | ENSP00000444688 | ENSP00000273077 | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.642 |
| ATP1A3 | PRRT2 | ENSP00000444688 | ENSP00000456226 | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | Proline rich transmembrane protein 2; Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family | 0.703 |
| ATP1A3 | SGCE | ENSP00000444688 | ENSP00000398930 | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.693 |
| ATP1A3 | THAP1 | ENSP00000444688 | ENSP00000254250 | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis; THAP domain containing | 0.717 |
| MAGEA11 | PNKD | ENSP00000347358 | ENSP00000273077 | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.681 |
| PET100 | PNKD | ENSP00000470539 | ENSP00000273077 | Protein PET100 homolog, mitochondrial; PET100 homolog; Belongs to the PET100 family | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.683 |
| PIP5KL1 | PNKD | ENSP00000373399 | ENSP00000273077 | Phosphatidylinositol-4-phosphate 5-kinase-like protein 1; Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.656 |
| PNKD | ASIC4 | ENSP00000273077 | ENSP00000326627 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity; Acid sensing ion channel subunits | 0.905 |
| PNKD | ATP1A3 | ENSP00000273077 | ENSP00000444688 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | 0.642 |
| PNKD | MAGEA11 | ENSP00000273077 | ENSP00000347358 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.681 |
| PNKD | PET100 | ENSP00000273077 | ENSP00000470539 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Protein PET100 homolog, mitochondrial; PET100 homolog; Belongs to the PET100 family | 0.683 |
| PNKD | PIP5KL1 | ENSP00000273077 | ENSP00000373399 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Phosphatidylinositol-4-phosphate 5-kinase-like protein 1; Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3 | 0.656 |
| PNKD | PRRT2 | ENSP00000273077 | ENSP00000456226 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Proline rich transmembrane protein 2; Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family | 0.686 |
| PNKD | SGCE | ENSP00000273077 | ENSP00000398930 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.661 |
| PNKD | THAP1 | ENSP00000273077 | ENSP00000254250 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis; THAP domain containing | 0.668 |
| PNKD | TMEM230 | ENSP00000273077 | ENSP00000341364 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles; Belongs to the TMEM134/TMEM230 family | 0.642 |
| PNKD | TOR2A | ENSP00000273077 | ENSP00000362381 | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Torsin-2A; Torsin family 2 member A; Belongs to the ClpA/ClpB family. Torsin subfamily | 0.702 |
| PRRT2 | ATP1A3 | ENSP00000456226 | ENSP00000444688 | Proline rich transmembrane protein 2; Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily | 0.703 |
| PRRT2 | PNKD | ENSP00000456226 | ENSP00000273077 | Proline rich transmembrane protein 2; Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family | Paroxysmal nonkinesiogenic dyskinesia protein; Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.686 |
STRING Database User Survey
