STRINGSTRING
PNKD protein (human) - STRING interaction network
"PNKD" - Probable hydrolase PNKD in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
PNKDProbable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family (385 aa)    
Predicted Functional Partners:
GPA33
Cell surface A33 antigen; May play a role in cell-cell recognition and signaling; IgCAM CXADR-related subfamily (319 aa)
           
  0.905
ASIC4
Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity; Acid sensing ion channel subunits (647 aa)
           
  0.807
PRRT2
Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family (394 aa)
           
  0.797
CATIP
Ciliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization (387 aa)
           
  0.727
TMEM165
Transmembrane protein 165; May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation (324 aa)
           
  0.686
SGCE
Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix (462 aa)
           
  0.668
ATP1A3
Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily (1026 aa)
     
   
  0.665
THAP1
THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5’-[AT]NTNN[GT]GGCA[AGT]-3’ core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis; THAP domain containing (213 aa)
           
  0.656
ATHL1
Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins (737 aa)
           
  0.645
SFXN1
Sideroflexin-1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria; Sideroflexins (322 aa)
           
  0.624
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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