node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASIC4 | PNKD | ENSP00000350786 | ENSP00000273077 | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.890 |
ASIC4 | SLC4A3 | ENSP00000350786 | ENSP00000273063 | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. | Anion exchange protein 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-); Belongs to the anion exchanger (TC 2.A.31) family. | 0.640 |
GAD1 | PNKD | ENSP00000350928 | ENSP00000273077 | Glutamate decarboxylase 1; Catalyzes the production of GABA. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.591 |
GCH1 | PNKD | ENSP00000477796 | ENSP00000273077 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.521 |
GCH1 | SGCE | ENSP00000477796 | ENSP00000496268 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.835 |
GCH1 | THAP1 | ENSP00000477796 | ENSP00000254250 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum- withdrawal and TNF-induced apoptosis. | 0.662 |
MAGEA11 | PNKD | ENSP00000347358 | ENSP00000273077 | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.683 |
PET100 | PET117 | ENSP00000470539 | ENSP00000397881 | Protein PET100 homolog, mitochondrial; PET100 cytochrome c oxidase chaperone; Belongs to the PET100 family. | Protein PET117 homolog, mitochondrial; PET117 cytochrome c oxidase chaperone. | 0.853 |
PET100 | PNKD | ENSP00000470539 | ENSP00000273077 | Protein PET100 homolog, mitochondrial; PET100 cytochrome c oxidase chaperone; Belongs to the PET100 family. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.902 |
PET117 | PET100 | ENSP00000397881 | ENSP00000470539 | Protein PET117 homolog, mitochondrial; PET117 cytochrome c oxidase chaperone. | Protein PET100 homolog, mitochondrial; PET100 cytochrome c oxidase chaperone; Belongs to the PET100 family. | 0.853 |
PET117 | PNKD | ENSP00000397881 | ENSP00000273077 | Protein PET117 homolog, mitochondrial; PET117 cytochrome c oxidase chaperone. | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | 0.913 |
PNKD | ASIC4 | ENSP00000273077 | ENSP00000350786 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity. | 0.890 |
PNKD | GAD1 | ENSP00000273077 | ENSP00000350928 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Glutamate decarboxylase 1; Catalyzes the production of GABA. | 0.591 |
PNKD | GCH1 | ENSP00000273077 | ENSP00000477796 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. Belongs to the GTP cyclohydrolase I family. | 0.521 |
PNKD | MAGEA11 | ENSP00000273077 | ENSP00000347358 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.683 |
PNKD | PET100 | ENSP00000273077 | ENSP00000470539 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Protein PET100 homolog, mitochondrial; PET100 cytochrome c oxidase chaperone; Belongs to the PET100 family. | 0.902 |
PNKD | PET117 | ENSP00000273077 | ENSP00000397881 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Protein PET117 homolog, mitochondrial; PET117 cytochrome c oxidase chaperone. | 0.913 |
PNKD | PRRT2 | ENSP00000273077 | ENSP00000456226 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation. | 0.963 |
PNKD | SGCE | ENSP00000273077 | ENSP00000496268 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.601 |
PNKD | SLC4A3 | ENSP00000273077 | ENSP00000273063 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. | Anion exchange protein 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-); Belongs to the anion exchanger (TC 2.A.31) family. | 0.598 |