node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD10 | ABHD11 | ENSP00000273359 | ENSP00000222800 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD11; Abhydrolase domain containing 11. | 0.607 |
ABHD10 | ABHD12B | ENSP00000273359 | ENSP00000336693 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | 0.568 |
ABHD10 | ABHD13 | ENSP00000273359 | ENSP00000365063 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD13; Abhydrolase domain containing 13. | 0.637 |
ABHD10 | ABHD16B | ENSP00000273359 | ENSP00000358932 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family. | 0.553 |
ABHD10 | ABHD17A | ENSP00000273359 | ENSP00000250974 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6 (By similarity). | 0.697 |
ABHD10 | ABHD17B | ENSP00000273359 | ENSP00000366240 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Alpha/beta hydrolase domain-containing protein 17B; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS ; Belongs to the AB hydrolase superfamily. ABHD17 family. | 0.611 |
ABHD10 | ABHD3 | ENSP00000273359 | ENSP00000289119 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. | 0.579 |
ABHD10 | ABHD6 | ENSP00000273359 | ENSP00000295962 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] | 0.567 |
ABHD10 | KCMF1 | ENSP00000273359 | ENSP00000386738 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | E3 ubiquitin-protein ligase KCMF1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination; Belongs to the KCMF1 family. | 0.626 |
ABHD10 | LYPLA1 | ENSP00000273359 | ENSP00000320043 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.562 |
ABHD11 | ABHD10 | ENSP00000222800 | ENSP00000273359 | Protein ABHD11; Abhydrolase domain containing 11. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | 0.607 |
ABHD11 | ABHD12B | ENSP00000222800 | ENSP00000336693 | Protein ABHD11; Abhydrolase domain containing 11. | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | 0.504 |
ABHD11 | ABHD13 | ENSP00000222800 | ENSP00000365063 | Protein ABHD11; Abhydrolase domain containing 11. | Protein ABHD13; Abhydrolase domain containing 13. | 0.548 |
ABHD11 | ABHD16B | ENSP00000222800 | ENSP00000358932 | Protein ABHD11; Abhydrolase domain containing 11. | Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family. | 0.530 |
ABHD11 | ABHD17A | ENSP00000222800 | ENSP00000250974 | Protein ABHD11; Abhydrolase domain containing 11. | Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6 (By similarity). | 0.478 |
ABHD11 | ABHD17B | ENSP00000222800 | ENSP00000366240 | Protein ABHD11; Abhydrolase domain containing 11. | Alpha/beta hydrolase domain-containing protein 17B; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS ; Belongs to the AB hydrolase superfamily. ABHD17 family. | 0.487 |
ABHD11 | ABHD3 | ENSP00000222800 | ENSP00000289119 | Protein ABHD11; Abhydrolase domain containing 11. | Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. | 0.582 |
ABHD11 | ABHD6 | ENSP00000222800 | ENSP00000295962 | Protein ABHD11; Abhydrolase domain containing 11. | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and [...] | 0.682 |
ABHD11 | LYPLA1 | ENSP00000222800 | ENSP00000320043 | Protein ABHD11; Abhydrolase domain containing 11. | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. | 0.601 |
ABHD12B | ABHD10 | ENSP00000336693 | ENSP00000273359 | Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family. | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belongs to the AB hydrolase superfamily. | 0.568 |