node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AK9 | TCTA | ENSP00000410186 | ENSP00000273590 | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.503 |
BLOC1S3 | GPR25 | ENSP00000393840 | ENSP00000301917 | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | Probable G-protein coupled receptor 25; Orphan receptor. | 0.560 |
BLOC1S3 | TCTA | ENSP00000393840 | ENSP00000273590 | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.421 |
GGTLC3 | TCTA | ENSP00000477856 | ENSP00000273590 | Gamma-glutamyltransferase light chain family member 3. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.447 |
GPR25 | BLOC1S3 | ENSP00000301917 | ENSP00000393840 | Probable G-protein coupled receptor 25; Orphan receptor. | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | 0.560 |
GPR25 | TCTA | ENSP00000301917 | ENSP00000273590 | Probable G-protein coupled receptor 25; Orphan receptor. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.508 |
OTOP3 | TCTA | ENSP00000464577 | ENSP00000273590 | Proton channel OTOP3; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.484 |
RIIAD1 | TCTA | ENSP00000419249 | ENSP00000273590 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | 0.429 |
TCTA | AK9 | ENSP00000273590 | ENSP00000410186 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. | 0.503 |
TCTA | BLOC1S3 | ENSP00000273590 | ENSP00000393840 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | 0.421 |
TCTA | GGTLC3 | ENSP00000273590 | ENSP00000477856 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | Gamma-glutamyltransferase light chain family member 3. | 0.447 |
TCTA | GPR25 | ENSP00000273590 | ENSP00000301917 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | Probable G-protein coupled receptor 25; Orphan receptor. | 0.508 |
TCTA | OTOP3 | ENSP00000273590 | ENSP00000464577 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | Proton channel OTOP3; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. Belongs to the otopetrin family. | 0.484 |
TCTA | RIIAD1 | ENSP00000273590 | ENSP00000419249 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1. | 0.429 |