node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS16 | ENSP00000387356 | ENSP00000274181 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.617 |
ACAN | NID1 | ENSP00000387356 | ENSP00000264187 | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. | 0.584 |
ADAMTS16 | ACAN | ENSP00000274181 | ENSP00000387356 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | 0.617 |
ADAMTS16 | B3GLCT | ENSP00000274181 | ENSP00000343002 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | 0.444 |
ADAMTS16 | GPC2 | ENSP00000274181 | ENSP00000292377 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Secreted glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Belongs to the glypican family. | 0.406 |
ADAMTS16 | IRX3 | ENSP00000274181 | ENSP00000331608 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | 0.451 |
ADAMTS16 | ISLR | ENSP00000274181 | ENSP00000249842 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Immunoglobulin superfamily containing leucine rich repeat. | 0.403 |
ADAMTS16 | NID1 | ENSP00000274181 | ENSP00000264187 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. | 0.443 |
ADAMTS16 | PI15 | ENSP00000274181 | ENSP00000260113 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.408 |
ADAMTS16 | POFUT2 | ENSP00000274181 | ENSP00000339613 | ADAM metallopeptidase with thrombospondin type 1 motif 16. | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and [...] | 0.406 |
B3GLCT | ADAMTS16 | ENSP00000343002 | ENSP00000274181 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.444 |
B3GLCT | POFUT2 | ENSP00000343002 | ENSP00000339613 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan. | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and [...] | 0.958 |
GPC2 | ADAMTS16 | ENSP00000292377 | ENSP00000274181 | Secreted glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Belongs to the glypican family. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.406 |
IRX3 | ADAMTS16 | ENSP00000331608 | ENSP00000274181 | Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.451 |
ISLR | ADAMTS16 | ENSP00000249842 | ENSP00000274181 | Immunoglobulin superfamily containing leucine rich repeat. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.403 |
ISLR | PI15 | ENSP00000249842 | ENSP00000260113 | Immunoglobulin superfamily containing leucine rich repeat. | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | 0.417 |
NID1 | ACAN | ENSP00000264187 | ENSP00000387356 | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. | 0.584 |
NID1 | ADAMTS16 | ENSP00000264187 | ENSP00000274181 | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.443 |
PI15 | ADAMTS16 | ENSP00000260113 | ENSP00000274181 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | ADAM metallopeptidase with thrombospondin type 1 motif 16. | 0.408 |
PI15 | ISLR | ENSP00000260113 | ENSP00000249842 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belongs to the CRISP family. | Immunoglobulin superfamily containing leucine rich repeat. | 0.417 |