SPINK7 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

SPINK7

Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor. (85 aa)

Predicted Functional Partners:

LYPD2

0.984

MRPS12

0.827

MT2A

0.819

RABL6

0.819

EPB42

0.802

MT1H

0.798

MT1G

0.787

CRNN

0.704

LYPD1

0.630

CAPN14

0.618

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPN14	SPINK7	ENSP00000385247	ENSP00000274565	Calpain-14; Calcium-regulated non-lysosomal thiol-protease.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.618
CRNN	SPINK7	ENSP00000271835	ENSP00000274565	Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.704
EPB42	SPINK7	ENSP00000497777	ENSP00000274565	Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.802
LYPD1	SPINK7	ENSP00000380605	ENSP00000274565	Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2- containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.630
LYPD2	SPINK7	ENSP00000352163	ENSP00000274565	LY6/PLAUR domain containing 2.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.984
MRPS12	SPINK7	ENSP00000384952	ENSP00000274565	Mitochondrial ribosomal protein S12.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.827
MT1G	MT1H	ENSP00000369139	ENSP00000330587	Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	0.978
MT1G	MT2A	ENSP00000369139	ENSP00000245185	Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	0.850
MT1G	SPINK7	ENSP00000369139	ENSP00000274565	Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.787
MT1H	MT1G	ENSP00000330587	ENSP00000369139	Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	0.978
MT1H	MT2A	ENSP00000330587	ENSP00000245185	Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	0.851
MT1H	SPINK7	ENSP00000330587	ENSP00000274565	Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.798
MT2A	MT1G	ENSP00000245185	ENSP00000369139	Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.	0.850
MT2A	MT1H	ENSP00000245185	ENSP00000330587	Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	0.851
MT2A	SPINK7	ENSP00000245185	ENSP00000274565	Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.819
RABL6	SPINK7	ENSP00000360727	ENSP00000274565	Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	0.819
SPINK7	CAPN14	ENSP00000274565	ENSP00000385247	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	Calpain-14; Calcium-regulated non-lysosomal thiol-protease.	0.618
SPINK7	CRNN	ENSP00000274565	ENSP00000271835	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family.	0.704
SPINK7	EPB42	ENSP00000274565	ENSP00000497777	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.	0.802
SPINK7	LYPD1	ENSP00000274565	ENSP00000380605	Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.	Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2- containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety.	0.630