node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAAH | PM20D2 | ENSP00000243167 | ENSP00000275072 | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Belongs to the amidase family. | Peptidase M20 domain containing 2. | 0.462 |
FAAH | QRSL1 | ENSP00000243167 | ENSP00000358042 | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Belongs to the amidase family. | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). | 0.410 |
GAPDH | PM20D2 | ENSP00000380070 | ENSP00000275072 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | Peptidase M20 domain containing 2. | 0.452 |
KLHL33 | PM20D2 | ENSP00000341549 | ENSP00000275072 | Kelch-like protein 33; Kelch like family member 33. | Peptidase M20 domain containing 2. | 0.515 |
MAPK1IP1L | PM20D2 | ENSP00000378851 | ENSP00000275072 | MAPK-interacting and spindle-stabilizing protein-like; Mitogen-activated protein kinase 1 interacting protein 1 like. | Peptidase M20 domain containing 2. | 0.529 |
MDN1 | PM20D2 | ENSP00000358400 | ENSP00000275072 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to [...] | Peptidase M20 domain containing 2. | 0.511 |
PGRMC2 | PM20D2 | ENSP00000481886 | ENSP00000275072 | Membrane-associated progesterone receptor component 2; Receptor for steroids. | Peptidase M20 domain containing 2. | 0.451 |
PM20D2 | FAAH | ENSP00000275072 | ENSP00000243167 | Peptidase M20 domain containing 2. | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Belongs to the amidase family. | 0.462 |
PM20D2 | GAPDH | ENSP00000275072 | ENSP00000380070 | Peptidase M20 domain containing 2. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.452 |
PM20D2 | KLHL33 | ENSP00000275072 | ENSP00000341549 | Peptidase M20 domain containing 2. | Kelch-like protein 33; Kelch like family member 33. | 0.515 |
PM20D2 | MAPK1IP1L | ENSP00000275072 | ENSP00000378851 | Peptidase M20 domain containing 2. | MAPK-interacting and spindle-stabilizing protein-like; Mitogen-activated protein kinase 1 interacting protein 1 like. | 0.529 |
PM20D2 | MDN1 | ENSP00000275072 | ENSP00000358400 | Peptidase M20 domain containing 2. | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to [...] | 0.511 |
PM20D2 | PGRMC2 | ENSP00000275072 | ENSP00000481886 | Peptidase M20 domain containing 2. | Membrane-associated progesterone receptor component 2; Receptor for steroids. | 0.451 |
PM20D2 | PNRC1 | ENSP00000275072 | ENSP00000336931 | Peptidase M20 domain containing 2. | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction. | 0.633 |
PM20D2 | QRSL1 | ENSP00000275072 | ENSP00000358042 | Peptidase M20 domain containing 2. | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). | 0.452 |
PM20D2 | UBE2J1 | ENSP00000275072 | ENSP00000451261 | Peptidase M20 domain containing 2. | Ubiquitin-conjugating enzyme E2 J1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. | 0.515 |
PM20D2 | ZKSCAN8 | ENSP00000275072 | ENSP00000332750 | Peptidase M20 domain containing 2. | Zinc finger protein with KRAB and SCAN domains 8; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.472 |
PNRC1 | PM20D2 | ENSP00000336931 | ENSP00000275072 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction. | Peptidase M20 domain containing 2. | 0.633 |
QRSL1 | FAAH | ENSP00000358042 | ENSP00000243167 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. Belongs to the amidase family. | 0.410 |
QRSL1 | PM20D2 | ENSP00000358042 | ENSP00000275072 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). | Peptidase M20 domain containing 2. | 0.452 |