node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BST2 | RTP4 | ENSP00000252593 | ENSP00000259030 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: h [...] | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16. Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). | 0.620 |
BST2 | TMEM140 | ENSP00000252593 | ENSP00000275767 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: h [...] | Transmembrane protein 140. | 0.420 |
CNIH4 | MVB12A | ENSP00000420443 | ENSP00000324810 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Belongs to the cornichon family. | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. | 0.468 |
CNIH4 | TMEM140 | ENSP00000420443 | ENSP00000275767 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Belongs to the cornichon family. | Transmembrane protein 140. | 0.437 |
KCNK7 | TMEM140 | ENSP00000344820 | ENSP00000275767 | Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | Transmembrane protein 140. | 0.404 |
MVB12A | CNIH4 | ENSP00000324810 | ENSP00000420443 | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Belongs to the cornichon family. | 0.468 |
MVB12A | TMEM140 | ENSP00000324810 | ENSP00000275767 | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. | Transmembrane protein 140. | 0.517 |
RTP4 | BST2 | ENSP00000259030 | ENSP00000252593 | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16. Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: h [...] | 0.620 |
RTP4 | TMEM140 | ENSP00000259030 | ENSP00000275767 | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16. Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). | Transmembrane protein 140. | 0.438 |
SH3RF3 | TMEM140 | ENSP00000309186 | ENSP00000275767 | E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity. | Transmembrane protein 140. | 0.446 |
TMEM140 | BST2 | ENSP00000275767 | ENSP00000252593 | Transmembrane protein 140. | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: h [...] | 0.420 |
TMEM140 | CNIH4 | ENSP00000275767 | ENSP00000420443 | Transmembrane protein 140. | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery. Belongs to the cornichon family. | 0.437 |
TMEM140 | KCNK7 | ENSP00000275767 | ENSP00000344820 | Transmembrane protein 140. | Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.404 |
TMEM140 | MVB12A | ENSP00000275767 | ENSP00000324810 | Transmembrane protein 140. | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. | 0.517 |
TMEM140 | RTP4 | ENSP00000275767 | ENSP00000259030 | Transmembrane protein 140. | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16. Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1 (By similarity). | 0.438 |
TMEM140 | SH3RF3 | ENSP00000275767 | ENSP00000309186 | Transmembrane protein 140. | E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity. | 0.446 |
TMEM140 | TMEM168 | ENSP00000275767 | ENSP00000323068 | Transmembrane protein 140. | Transmembrane protein 168; Belongs to the TMEM168 family. | 0.453 |
TMEM140 | TRANK1 | ENSP00000275767 | ENSP00000494480 | Transmembrane protein 140. | Tetratricopeptide repeat and ankyrin repeat containing 1. | 0.400 |
TMEM168 | TMEM140 | ENSP00000323068 | ENSP00000275767 | Transmembrane protein 168; Belongs to the TMEM168 family. | Transmembrane protein 140. | 0.453 |
TRANK1 | TMEM140 | ENSP00000494480 | ENSP00000275767 | Tetratricopeptide repeat and ankyrin repeat containing 1. | Transmembrane protein 140. | 0.400 |