Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin- stimulated transcription.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF [...]

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Olfactory receptor 5AK2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Prolyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Suppressor of fused homolog; Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down-regulates GLI2-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of eit [...]

Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin- stimulated transcription.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin- stimulated transcription.

Olfactory receptor 5AK2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.

IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.

Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.

IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.

Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.

Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF [...]

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF [...]

E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.

Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF [...]

Suppressor of fused homolog; Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down-regulates GLI2-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of eit [...]

Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.

Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.