STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAGEA4Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. (317 aa)    
Predicted Functional Partners:
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family.
   
  
 0.946
CTAG2
Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family.
   
  
 0.924
RAD18
E3 ubiquitin-protein ligase RAD18; E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. Has ssDNA binding activity.
   
 
 0.888
MAGEA10
Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
  
 
0.863
HLA-A
HLA class I histocompatibility antigen, A alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells. May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usuall [...]
    
 
 0.790
TRIM69
E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.
   
 
 0.763
PRAME
Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.
   
  
 0.739
SSX2
SSX family member 2.
   
  
 0.720
SSX2B
SSX family member 2B.
   
  
 0.706
MAGEA9
Melanoma-associated antigen 9; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
  
 
0.651
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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