C8orf76 protein (human) - STRING interaction network

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C8orf76

Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76. (380 aa)

Predicted Functional Partners:

NSMCE2

0.498

COMMD5

0.497

ZNF623

0.497

TIGD5

0.477

POP1

0.473

NUDCD1

0.466

C8orf33

0.465

FAM83H

0.462

MTERF3

0.437

UBR5

0.437

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C8orf33	C8orf76	ENSP00000330361	ENSP00000276704	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	0.465
C8orf33	COMMD5	ENSP00000330361	ENSP00000394331	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.	0.473
C8orf33	NUDCD1	ENSP00000330361	ENSP00000239690	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	NudC domain containing 1.	0.462
C8orf33	POP1	ENSP00000330361	ENSP00000385787	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.506
C8orf33	TIGD5	ENSP00000330361	ENSP00000421489	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	Tigger transposable element derived 5.	0.437
C8orf33	ZNF623	ENSP00000330361	ENSP00000445979	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	Zinc finger protein 623; May be involved in transcriptional regulation.	0.459
C8orf76	C8orf33	ENSP00000276704	ENSP00000330361	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	0.465
C8orf76	COMMD5	ENSP00000276704	ENSP00000394331	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.	0.497
C8orf76	FAM83H	ENSP00000276704	ENSP00000373565	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration.	0.462
C8orf76	MTERF3	ENSP00000276704	ENSP00000287025	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity); Belongs to the mTERF family.	0.437
C8orf76	NSMCE2	ENSP00000276704	ENSP00000287437	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin com [...]	0.498
C8orf76	NUDCD1	ENSP00000276704	ENSP00000239690	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	NudC domain containing 1.	0.466
C8orf76	POP1	ENSP00000276704	ENSP00000385787	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.	0.473
C8orf76	TIGD5	ENSP00000276704	ENSP00000421489	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	Tigger transposable element derived 5.	0.477
C8orf76	UBR5	ENSP00000276704	ENSP00000429084	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Pl [...]	0.437
C8orf76	ZNF623	ENSP00000276704	ENSP00000445979	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	Zinc finger protein 623; May be involved in transcriptional regulation.	0.497
COMMD5	C8orf33	ENSP00000394331	ENSP00000330361	COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.	UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.	0.473
COMMD5	C8orf76	ENSP00000394331	ENSP00000276704	COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.	Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.	0.497
COMMD5	TIGD5	ENSP00000394331	ENSP00000421489	COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.	Tigger transposable element derived 5.	0.687
COMMD5	ZNF623	ENSP00000394331	ENSP00000445979	COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B.	Zinc finger protein 623; May be involved in transcriptional regulation.	0.450