node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf40 | PROSER2 | ENSP00000403987 | ENSP00000277570 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | Proline and serine rich 2. | 0.560 |
CD180 | FATE1 | ENSP00000256447 | ENSP00000359375 | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). | Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. | 0.476 |
CD180 | PROSER2 | ENSP00000256447 | ENSP00000277570 | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). | Proline and serine rich 2. | 0.539 |
CDC42EP4 | PROSER2 | ENSP00000338258 | ENSP00000277570 | Cdc42 effector protein 4; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts; Belongs to the BORG/CEP family. | Proline and serine rich 2. | 0.500 |
ECHDC3 | PROSER2 | ENSP00000368517 | ENSP00000277570 | Enoyl-CoA hydratase domain-containing protein 3, mitochondrial; May play a role in fatty acid biosynthesis and insulin sensitivity; Belongs to the enoyl-CoA hydratase/isomerase family. | Proline and serine rich 2. | 0.507 |
FAM199X | PROSER2 | ENSP00000417581 | ENSP00000277570 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family. | Proline and serine rich 2. | 0.452 |
FATE1 | CD180 | ENSP00000359375 | ENSP00000256447 | Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). | 0.476 |
FATE1 | PROSER2 | ENSP00000359375 | ENSP00000277570 | Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. | Proline and serine rich 2. | 0.659 |
LRRC75B | PROSER2 | ENSP00000320520 | ENSP00000277570 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | Proline and serine rich 2. | 0.581 |
PDCD10 | PROSER2 | ENSP00000376506 | ENSP00000277570 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | Proline and serine rich 2. | 0.551 |
PDCD10 | STK24 | ENSP00000376506 | ENSP00000365730 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] | 0.999 |
PROSER2 | C15orf40 | ENSP00000277570 | ENSP00000403987 | Proline and serine rich 2. | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40. | 0.560 |
PROSER2 | CD180 | ENSP00000277570 | ENSP00000256447 | Proline and serine rich 2. | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity). | 0.539 |
PROSER2 | CDC42EP4 | ENSP00000277570 | ENSP00000338258 | Proline and serine rich 2. | Cdc42 effector protein 4; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts; Belongs to the BORG/CEP family. | 0.500 |
PROSER2 | ECHDC3 | ENSP00000277570 | ENSP00000368517 | Proline and serine rich 2. | Enoyl-CoA hydratase domain-containing protein 3, mitochondrial; May play a role in fatty acid biosynthesis and insulin sensitivity; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.507 |
PROSER2 | FAM199X | ENSP00000277570 | ENSP00000417581 | Proline and serine rich 2. | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family. | 0.452 |
PROSER2 | FATE1 | ENSP00000277570 | ENSP00000359375 | Proline and serine rich 2. | Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. | 0.659 |
PROSER2 | LRRC75B | ENSP00000277570 | ENSP00000320520 | Proline and serine rich 2. | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B. | 0.581 |
PROSER2 | PDCD10 | ENSP00000277570 | ENSP00000376506 | Proline and serine rich 2. | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Belongs to the PDCD10 family. | 0.551 |
PROSER2 | STK24 | ENSP00000277570 | ENSP00000365730 | Proline and serine rich 2. | Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] | 0.623 |