STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C11orf52Uncharacterized protein C11orf52; Chromosome 11 open reading frame 52 (123 aa)    
Predicted Functional Partners:
FRMD4A
FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing
      
 0.556
ZNF189
Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family
      
 0.470
TMEM86A
Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A
      
 0.463
TMEM51
Transmembrane protein 51
      
 0.459
IFFO1
Intermediate filament family orphan 1; Belongs to the intermediate filament family
      
 0.459
TMEM87A
Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)
      
 0.426
MT1HL1
Metallothionein 1H-like protein 1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids
      
 0.424
AAMDC
Mth938 domain-containing protein; May play a role in preadipocyte differentiation and adipogenesis; Belongs to the AAMDC family
      
 0.422
ZSWIM5
Zinc finger swim domain-containing protein 5; Zinc finger SWIM-type containing 5
      
 0.420
PPEF2
Serine/threonine-protein phosphatase with EF-hands 2; May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission; Belongs to the PPP phosphatase family
      
 0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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