STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1755Uncharacterized protein KIAA1755; KIAA1755. (1200 aa)    
Predicted Functional Partners:
SYT10
Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
      
 0.542
C11orf71
Uncharacterized protein C11orf71; Chromosome 11 open reading frame 71.
      
 0.496
RANBP3L
Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner.
   
  
 0.492
SLC35F1
Solute carrier family 35 member F1; Putative solute transporter.
      
 0.489
RWDD2A
RWD domain containing 2A.
      
 0.484
SLC6A7
Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals.
   
  
 0.480
ZBTB47
Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation.
   
  
 0.460
EPB41L4A
Erythrocyte membrane protein band 4.1 like 4A.
   
  
 0.460
VSTM2L
V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.
   
  
 0.456
ITM2C
Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
      
 0.454
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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