PRB4 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C4BPA	PRB1	ENSP00000356037	ENSP00000420826	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	0.764
C4BPA	PRB2	ENSP00000356037	ENSP00000374013	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	0.692
C4BPA	PRB3	ENSP00000356037	ENSP00000442626	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum.	0.706
C4BPA	PRB4	ENSP00000356037	ENSP00000279575	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4.	0.729
C4BPA	PRH1	ENSP00000356037	ENSP00000479168	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Proline rich protein HaeIII subfamily 1.	0.725
C4BPA	PRH2	ENSP00000356037	ENSP00000379682	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Salivary acidic proline-rich phosphoprotein 1/2; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.	0.758
C4BPA	STATH	ENSP00000356037	ENSP00000246895	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.570
CST5	PRB1	ENSP00000307132	ENSP00000420826	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	0.608
CST5	PRB2	ENSP00000307132	ENSP00000374013	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	0.624
CST5	PRB3	ENSP00000307132	ENSP00000442626	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum.	0.645
CST5	PRB4	ENSP00000307132	ENSP00000279575	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4.	0.688
CST5	PRH1	ENSP00000307132	ENSP00000479168	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Proline rich protein HaeIII subfamily 1.	0.698
CST5	SMR3B	ENSP00000307132	ENSP00000481313	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family.	0.577
CST5	STATH	ENSP00000307132	ENSP00000246895	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.	0.445
PRB1	C4BPA	ENSP00000420826	ENSP00000356037	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	0.764
PRB1	CST5	ENSP00000420826	ENSP00000307132	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.	0.608
PRB1	PRB2	ENSP00000420826	ENSP00000374013	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.	0.993
PRB1	PRB3	ENSP00000420826	ENSP00000442626	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum.	0.945
PRB1	PRB4	ENSP00000420826	ENSP00000279575	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4.	0.998
PRB1	PRH1	ENSP00000420826	ENSP00000479168	Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.	Proline rich protein HaeIII subfamily 1.	0.832