STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM124AProtein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family. (582 aa)    
Predicted Functional Partners:
FAM167B
Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family.
   
  
 0.567
WDR49
WD repeat domain 49.
   
  
 0.513
SERPINE3
Serpin E3; Probable serine protease inhibitor.
 
    
 0.499
FAM160B1
Protein FAM160B1; Family with sequence similarity 160 member B1.
      
 0.485
SPACA9
Sperm acrosome associated 9.
      
 0.481
TMIGD3
Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity.
      
 0.470
PRKG1
cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...]
   
   0.468
CCDC157
Coiled-coil domain containing 157.
   
    0.461
ANKRD29
Ankyrin repeat domain 29.
   
 
 0.454
PDLIM3
PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells.
   
  
 0.449
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.