Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SPATA4Spermatogenesis-associated protein 4; May play a role in apoptosis regulation. (305 aa)    
Predicted Functional Partners:
SPATA17
Spermatogenesis-associated protein 17; Spermatogenesis associated 17.
   
 
 0.903
SPAG17
Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts.
   
 
 0.807
SPAG6
Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
   
 
 0.788
WDR90
WD repeat-containing protein 90; Required for efficient primary cilium formation.
    
   0.764
HYDIN
Hydrocephalus-inducing protein homolog; Required for ciliary motility.
   
 
 0.716
CFAP47
Cilia and flagella associated protein 47.
   
 
 0.694
LRRC43
Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43.
   
 
 0.687
CFAP69
Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability.
   
 
 0.682
LRGUK
Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis.
    
 
 0.672
MYCBPAP
MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).
   
 
 0.670
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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