C11orf53 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf53	COLCA2	ENSP00000489630	ENSP00000484135	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	Colorectal cancer associated 2.	0.863
C11orf53	NHLRC4	ENSP00000489630	ENSP00000410858	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	NHL-repeat-containing protein 4; NHL repeat containing 4.	0.553
C11orf53	POU2AF1	ENSP00000489630	ENSP00000376786	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.	0.554
C11orf53	POU2F1	ENSP00000489630	ENSP00000356840	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.	0.752
C11orf53	POU2F2	ENSP00000489630	ENSP00000431603	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class-2 subfamily.	0.737
C11orf53	POU2F3	ENSP00000489630	ENSP00000260264	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.	0.928
C11orf53	PSORS1C1	ENSP00000489630	ENSP00000259881	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	Psoriasis susceptibility 1 candidate 1.	0.566
C11orf53	SERTAD3	ENSP00000489630	ENSP00000375882	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	SERTA domain-containing protein 3; Strong transcriptional coactivator.	0.614
C11orf53	SFTA2	ENSP00000489630	ENSP00000351989	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	Surfactant-associated protein 2; Putative surfactant protein.	0.551
C11orf53	TAC4	ENSP00000489630	ENSP00000334042	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	0.584
COLCA2	C11orf53	ENSP00000484135	ENSP00000489630	Colorectal cancer associated 2.	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	0.863
COLCA2	POU2AF1	ENSP00000484135	ENSP00000376786	Colorectal cancer associated 2.	POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.	0.494
COLCA2	POU2F3	ENSP00000484135	ENSP00000260264	Colorectal cancer associated 2.	POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen.	0.922
NHLRC4	C11orf53	ENSP00000410858	ENSP00000489630	NHL-repeat-containing protein 4; NHL repeat containing 4.	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	0.553
NHLRC4	PSORS1C1	ENSP00000410858	ENSP00000259881	NHL-repeat-containing protein 4; NHL repeat containing 4.	Psoriasis susceptibility 1 candidate 1.	0.587
NHLRC4	TAC4	ENSP00000410858	ENSP00000334042	NHL-repeat-containing protein 4; NHL repeat containing 4.	Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.	0.690
POU2AF1	C11orf53	ENSP00000376786	ENSP00000489630	POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.	Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.	0.554
POU2AF1	COLCA2	ENSP00000376786	ENSP00000484135	POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.	Colorectal cancer associated 2.	0.494
POU2AF1	POU2F1	ENSP00000376786	ENSP00000356840	POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.	POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.	0.992
POU2AF1	POU2F2	ENSP00000376786	ENSP00000431603	POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.	POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class-2 subfamily.	0.925