TMEM86A protein (human) - STRING interaction network

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TMEM86A

Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A. (240 aa)

Predicted Functional Partners:

NXPH2

0.514

LRRC3C

0.484

CLCA2

0.471

LHFPL2

0.467

PPP1R14B

0.465

GET3

0.459

TSPAN2

0.456

TMEM51

0.449

DLST

0.446

PRODH

0.444

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCA2	TMEM86A	ENSP00000359596	ENSP00000280734	Calcium-activated chloride channel regulator 2, 109 kDa form; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family.	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.471
DLST	TMEM86A	ENSP00000335304	ENSP00000280734	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl- CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone s [...]	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.446
GET3	TMEM86A	ENSP00000466379	ENSP00000280734	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.459
LHFPL2	TMEM51	ENSP00000369702	ENSP00000365176	LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development.	Transmembrane protein 51.	0.484
LHFPL2	TMEM86A	ENSP00000369702	ENSP00000280734	LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development.	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.467
LRRC3C	NXPH2	ENSP00000367157	ENSP00000272641	Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C.	Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.	0.407
LRRC3C	TMEM86A	ENSP00000367157	ENSP00000280734	Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C.	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.484
NXPH2	LRRC3C	ENSP00000272641	ENSP00000367157	Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.	Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C.	0.407
NXPH2	TMEM86A	ENSP00000272641	ENSP00000280734	Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.514
PPP1R14B	TMEM86A	ENSP00000310117	ENSP00000280734	Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.465
PRODH	TMEM86A	ENSP00000349577	ENSP00000280734	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.444
TMEM51	LHFPL2	ENSP00000365176	ENSP00000369702	Transmembrane protein 51.	LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development.	0.484
TMEM51	TMEM86A	ENSP00000365176	ENSP00000280734	Transmembrane protein 51.	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	0.449
TMEM86A	CLCA2	ENSP00000280734	ENSP00000359596	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	Calcium-activated chloride channel regulator 2, 109 kDa form; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family.	0.471
TMEM86A	DLST	ENSP00000280734	ENSP00000335304	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl- CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone s [...]	0.446
TMEM86A	GET3	ENSP00000280734	ENSP00000466379	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]	0.459
TMEM86A	LHFPL2	ENSP00000280734	ENSP00000369702	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development.	0.467
TMEM86A	LRRC3C	ENSP00000280734	ENSP00000367157	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C.	0.484
TMEM86A	NXPH2	ENSP00000280734	ENSP00000272641	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.	0.514
TMEM86A	PPP1R14B	ENSP00000280734	ENSP00000310117	Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.	Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).	0.465