node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHDH | MIOX | ENSP00000221403 | ENSP00000216075 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Myo-inositol oxygenase. | 0.453 |
DHDH | SLC2A13 | ENSP00000221403 | ENSP00000280871 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.466 |
GFOD2 | SLC2A13 | ENSP00000268797 | ENSP00000280871 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.454 |
ISYNA1 | MIOX | ENSP00000337746 | ENSP00000216075 | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. | Myo-inositol oxygenase. | 0.701 |
ISYNA1 | SLC2A13 | ENSP00000337746 | ENSP00000280871 | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.476 |
ISYNA1 | SLC5A3 | ENSP00000337746 | ENSP00000370543 | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. | Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.479 |
MIOX | DHDH | ENSP00000216075 | ENSP00000221403 | Myo-inositol oxygenase. | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | 0.453 |
MIOX | ISYNA1 | ENSP00000216075 | ENSP00000337746 | Myo-inositol oxygenase. | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. | 0.701 |
MIOX | SLC2A13 | ENSP00000216075 | ENSP00000280871 | Myo-inositol oxygenase. | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.467 |
MIOX | SLC5A3 | ENSP00000216075 | ENSP00000370543 | Myo-inositol oxygenase. | Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.463 |
SLC22A2 | SLC2A11 | ENSP00000355920 | ENSP00000483038 | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | Solute carrier family 2, facilitated glucose transporter member 11; Facilitative glucose transporter. | 0.459 |
SLC22A2 | SLC2A13 | ENSP00000355920 | ENSP00000280871 | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.470 |
SLC2A11 | SLC22A2 | ENSP00000483038 | ENSP00000355920 | Solute carrier family 2, facilitated glucose transporter member 11; Facilitative glucose transporter. | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] | 0.459 |
SLC2A11 | SLC2A13 | ENSP00000483038 | ENSP00000280871 | Solute carrier family 2, facilitated glucose transporter member 11; Facilitative glucose transporter. | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.494 |
SLC2A11 | SLC5A11 | ENSP00000483038 | ENSP00000289932 | Solute carrier family 2, facilitated glucose transporter member 11; Facilitative glucose transporter. | Sodium/myo-inositol cotransporter 2; Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D- chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney; Belongs to the sodium:solute symporter (SSF) (TC 2 [...] | 0.425 |
SLC2A11-2 | SLC2A13 | ENSP00000400325 | ENSP00000280871 | MFS domain-containing protein. | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.792 |
SLC2A11-2 | SLC5A11 | ENSP00000400325 | ENSP00000289932 | MFS domain-containing protein. | Sodium/myo-inositol cotransporter 2; Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D- chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney; Belongs to the sodium:solute symporter (SSF) (TC 2 [...] | 0.446 |
SLC2A13 | DHDH | ENSP00000280871 | ENSP00000221403 | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family. | 0.466 |
SLC2A13 | GFOD2 | ENSP00000280871 | ENSP00000268797 | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly. | 0.454 |
SLC2A13 | ISYNA1 | ENSP00000280871 | ENSP00000337746 | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. | 0.476 |