FAM177A1 protein (human) - STRING interaction network

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Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCN7	FAM177A1	ENSP00000372193	ENSP00000280987	H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.529
FAM177A1	CLCN7	ENSP00000280987	ENSP00000372193	Protein FAM177A1; Family with sequence similarity 177 member A1.	H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily.	0.529
FAM177A1	FAM204A	ENSP00000280987	ENSP00000358183	Protein FAM177A1; Family with sequence similarity 177 member A1.	Protein FAM204A; Family with sequence similarity 204 member A.	0.626
FAM177A1	GPKOW	ENSP00000280987	ENSP00000156109	Protein FAM177A1; Family with sequence similarity 177 member A1.	G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing.	0.612
FAM177A1	GTF2F2	ENSP00000280987	ENSP00000340823	Protein FAM177A1; Family with sequence similarity 177 member A1.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.572
FAM177A1	ODR4	ENSP00000280987	ENSP00000287859	Protein FAM177A1; Family with sequence similarity 177 member A1.	Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family.	0.776
FAM177A1	RHOJ	ENSP00000280987	ENSP00000316729	Protein FAM177A1; Family with sequence similarity 177 member A1.	Rho-related GTP-binding protein RhoJ; Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration.	0.714
FAM177A1	SRP54	ENSP00000280987	ENSP00000451818	Protein FAM177A1; Family with sequence similarity 177 member A1.	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).	0.562
FAM177A1	TGS1	ENSP00000280987	ENSP00000260129	Protein FAM177A1; Family with sequence similarity 177 member A1.	Trimethylguanosine synthase; Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.	0.600
FAM177A1	UFSP2	ENSP00000280987	ENSP00000264689	Protein FAM177A1; Family with sequence similarity 177 member A1.	Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.	0.531
FAM177A1	VPS13B	ENSP00000280987	ENSP00000351346	Protein FAM177A1; Family with sequence similarity 177 member A1.	Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family.	0.711
FAM204A	FAM177A1	ENSP00000358183	ENSP00000280987	Protein FAM204A; Family with sequence similarity 204 member A.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.626
GPKOW	FAM177A1	ENSP00000156109	ENSP00000280987	G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.612
GTF2F2	FAM177A1	ENSP00000340823	ENSP00000280987	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.572
ODR4	FAM177A1	ENSP00000287859	ENSP00000280987	Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.776
ODR4	UFSP2	ENSP00000287859	ENSP00000264689	Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family.	Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.	0.939
RHOJ	FAM177A1	ENSP00000316729	ENSP00000280987	Rho-related GTP-binding protein RhoJ; Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.714
SRP54	FAM177A1	ENSP00000451818	ENSP00000280987	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.562
TGS1	FAM177A1	ENSP00000260129	ENSP00000280987	Trimethylguanosine synthase; Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.600
UFSP2	FAM177A1	ENSP00000264689	ENSP00000280987	Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.	Protein FAM177A1; Family with sequence similarity 177 member A1.	0.531