GMCL1 protein (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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same PNG format, but at higher resolution

... as a vector graphic:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM167A	GMCL1	ENSP00000284486	ENSP00000282570	Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family.	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	0.843
GAGE10	GMCL1	ENSP00000385415	ENSP00000282570	G antigen 10; Belongs to the GAGE family.	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	0.839
GAGE12G	GAGE2A	ENSP00000416249	ENSP00000355421	G antigen 12G.	G antigen 2A.	0.910
GAGE12G	GAGE2E	ENSP00000416249	ENSP00000478568	G antigen 12G.	G antigen 2E.	0.975
GAGE12G	GMCL1	ENSP00000416249	ENSP00000282570	G antigen 12G.	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	0.811
GAGE2A	GAGE12G	ENSP00000355421	ENSP00000416249	G antigen 2A.	G antigen 12G.	0.910
GAGE2A	GAGE2E	ENSP00000355421	ENSP00000478568	G antigen 2A.	G antigen 2E.	0.532
GAGE2A	GMCL1	ENSP00000355421	ENSP00000282570	G antigen 2A.	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	0.623
GAGE2E	GAGE12G	ENSP00000478568	ENSP00000416249	G antigen 2E.	G antigen 12G.	0.975
GAGE2E	GAGE2A	ENSP00000478568	ENSP00000355421	G antigen 2E.	G antigen 2A.	0.532
GAGE2E	GMCL1	ENSP00000478568	ENSP00000282570	G antigen 2E.	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	0.626
GMCL1	FAM167A	ENSP00000282570	ENSP00000284486	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family.	0.843
GMCL1	GAGE10	ENSP00000282570	ENSP00000385415	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	G antigen 10; Belongs to the GAGE family.	0.839
GMCL1	GAGE12G	ENSP00000282570	ENSP00000416249	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	G antigen 12G.	0.811
GMCL1	GAGE2A	ENSP00000282570	ENSP00000355421	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	G antigen 2A.	0.623
GMCL1	GAGE2E	ENSP00000282570	ENSP00000478568	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	G antigen 2E.	0.626
GMCL1	PAX4	ENSP00000282570	ENSP00000368014	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.	0.608
GMCL1	PBXIP1	ENSP00000282570	ENSP00000357448	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.	0.794
GMCL1	SPATA4	ENSP00000282570	ENSP00000280191	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	Spermatogenesis-associated protein 4; May play a role in apoptosis regulation.	0.596
GMCL1	XAGE2	ENSP00000282570	ENSP00000286049	Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By similarity).	X antigen family member 2.	0.965