node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHSG | BAMBI | ENSP00000393887 | ENSP00000364683 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | 0.908 |
AHSG | BMP6 | ENSP00000393887 | ENSP00000283147 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | 0.904 |
AHSG | BMPR1A | ENSP00000393887 | ENSP00000361107 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.903 |
AHSG | BMPR1B | ENSP00000393887 | ENSP00000401907 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.901 |
AHSG | BMPR2 | ENSP00000393887 | ENSP00000363708 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.905 |
AHSG | HFE2 | ENSP00000393887 | ENSP00000337014 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis; Belongs to the repulsive guidance molecule (RGM) family | 0.907 |
BAMBI | AHSG | ENSP00000364683 | ENSP00000393887 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | 0.908 |
BAMBI | BMP6 | ENSP00000364683 | ENSP00000283147 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | 0.943 |
BAMBI | BMPR1A | ENSP00000364683 | ENSP00000361107 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.959 |
BAMBI | BMPR1B | ENSP00000364683 | ENSP00000401907 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.954 |
BAMBI | BMPR2 | ENSP00000364683 | ENSP00000363708 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.950 |
BAMBI | HFE2 | ENSP00000364683 | ENSP00000337014 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis; Belongs to the repulsive guidance molecule (RGM) family | 0.915 |
BAMBI | NOG | ENSP00000364683 | ENSP00000328181 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 | 0.953 |
BAMBI | SMAD5 | ENSP00000364683 | ENSP00000441954 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) | 0.431 |
BMP6 | AHSG | ENSP00000283147 | ENSP00000393887 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 | 0.904 |
BMP6 | BAMBI | ENSP00000283147 | ENSP00000364683 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family | 0.943 |
BMP6 | BMPR1A | ENSP00000283147 | ENSP00000361107 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.986 |
BMP6 | BMPR1B | ENSP00000283147 | ENSP00000401907 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.984 |
BMP6 | BMPR2 | ENSP00000283147 | ENSP00000363708 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily | 0.988 |
BMP6 | HFE2 | ENSP00000283147 | ENSP00000337014 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins | Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis; Belongs to the repulsive guidance molecule (RGM) family | 0.907 |